ICP-OES法测定康艾注射液原料药中重金属元素的含量

Determination of Impurity Heavy Metal Elements in KangAi Injection raw medicine by ICP-OES

目的建立精准便捷检测康艾注射液原料药中多种重金属元素含量的方法。方法采用电感耦合等离子体发射光谱法(ICP-OES)检测康艾注射液原料药中各种杂质元素的含量,工作参数为射频功率1.4kW,等离子体气流速为14L·min-1,辅助气流速度为0.2L·min-1,雾化气流速度为0.6L·min-1,蠕动泵速为0.8L·min-1,以轴向方式采集信号。结果ICP-OES法检测康艾注射液原料药中砷、钡、钴、铬、铜、汞、锰、镍、铅(As、Ba、Cd、Co、Cr、Cu、Hg、Mn、Ni、Pb)等元素均具有良好的检出限、精密度、重复性和准确度。结论ICP-OES能够准确快捷检测康艾注射液原料药中多种重金属元素,对提高康艾注射液的质量标准具有参考意义。

OBJECTIVE To establish an accurate and convenient method to detect the content of various heavy met als in KangAi injection.METHODS Inductively coupled plasma atomic emission spectrometry(ICP-OES)was used to determine various impurities in KangAi injection with radio-frequency power 1.4kW,plasma gas flow rate of 14L·min-1,auxiliary gas flow rate of 0.2L·min-1,atomizing air speed of 0.6L·min-1,the peristaltic pump speed was 0.8L·min-1 and the axial direction for signal acquisition.RESULTS As,Ba,Cd,Co,Cr,Cu,Hg,Mn,Ni,Pb in KangAi injection were detected by ICP-OES got desirable detection limit,precision,repeatability and accuracy.CONCLUSION ICP-OES could detect various heavy met al elements in KangAi injection accurately and effectively,which improve the quality of reference standard of KangAi injection.