人体肺腺泡区多肺泡模型的建立和重力方向对颗粒物沉积影响的数值模拟研究

Multi-alveolar model and numerical simulation of influence of gravity direction on inhaled particle deposition in human pulmonary acinus region

目的针对现行人体肺腺泡模型与实际差异过大问题,建立更加符合实际的人体肺腺泡模型并采用该模型数值模拟研究重力方向对人体肺腺泡区颗粒物沉积的影响。方法采用Inventor 2016建立人体肺腺泡模型,采用fluent 15.0数值模拟重力方向的影响。结果建立的“柱状气管+球状肺泡”架构多肺泡模型各项数据与文献一致;重力方向对颗粒物在肺腺泡区总体沉积率影响不大,但会显著影响颗粒物沉积位置。结论建立的“柱状气管+球状肺泡”架构的多肺泡模型能满足不同研究对模型的需要,重力方向是影响颗粒物沉积的重要因素。

Objective To establish a more realistic human lung acinar model that can be used to simulate the influence of gravity direction on the deposition of inhaled particles in the human pulmonary acinus region.Methods Inventor 2016 was used to establish a human lung acinar model,and the influence of gravity direction was simulated by fluent 15.0.Results The data of the multi-alveolar model of the"columnar tracheal+spheroidal alveolar"structure was consistent with literature.The gravity direction had little effect on the total deposition fraction of inhaled particles in the human pulmonary acinus region,but it could significantly affect the location of particle deposition.Conclusion The multialveolar model of the"columnar tracheal+spheroidal alveolar"structure can meet the needs of different research for models.Gravity direction is an important factor that affects the deposition of particles.