扑草净在环境和生物体内的降解代谢、毒性及安全性评价研究进展

Research progress: degradation, metabolism, toxicity and safety evaluation of prometryne in environment and organisms

均三氮苯类除草剂扑草净常用于农业防除禾本科及阔叶杂草,并在水产养殖业违规使用作为环境改良剂以清除青苔等有害藻类和水草,其性质稳定难降解并通过食物链对人体产生危害,是可疑的内分泌干扰物,扑草净及其种类繁多结构多样的降解代谢产物长期暴露,可能引起潜在毒性效应及水域生态环境群落的衰退。本文中系统地综述了扑草净在环境和动植物体内的降解代谢途径、各代谢产物分子结构组成及转化,扑草净对机体内分泌和免疫功能等的影响,以及对人体健康和生态环境的安全评价方法。本研究结果可为开展扑草净对人体健康和生态环境潜在危害的研究和进行准确的安全性评价提供依据。

S-triazine herbicide prometryn is commonly applied to eradicate gramineae grasses and broad-leaf weeds in agriculture and illegally as an environmental improver to remove harmful algae and aquatic weeds in aquaculture industry.It as a suspected endocrine disruptor is stable in environment,difficult to be degraded and harmful to human through food chain.This paper reviews the degradation and metabolic pathways of prometryn,the structure and distribution of metabolic degradation products in environment,animals and plants,and the effects of prometryn on endocrine and immune functions,and the evaluation methods for human health and ecological environment safety.The extensive uses of prometryn result in a variety of metabolic degradation products with varied structures.The potential toxicity caused by long-term exposure to prometryn and various metabolites and the decline of ecological community population in environment will be the focus of our attention in the future.