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Multiple sgRNAs facilitate base editingmediated i-stop to induce complete and precise gene disruption 被引量:4

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摘要 Dear Editor,Gene editing is a process to introduce desired changes into targeted loci of genomic DNA.Recently,type II clustered regularly in terspaced short palindromic repeats-associated Cas9 endonuclease(CRISPR/Cas9)system has been demonstrated as a versatile tool for engineering eukaryote genome(Hsu et al.,2014),such as in mice(Zuo et al.,2017).
出处 《Protein & Cell》 SCIE CAS CSCD 2019年第11期832-839,共8页 蛋白质与细胞(英文版)
基金 The authors declare no Competing Financial or Non-Financial Interests.This work was supported by National Center for International Research(2017B01012) National Natural Science Foundation of China(Grant Nos.31771299,81600380 and 31600958) Natural Science Foundation of Jiangsu Proving(BK20160313,BK20160317).
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