组织蛋白酶S在肾脏及风湿疾病中的研究进展

Progresses of cathepsin S in kidney and rheumatic diseases

组织蛋白酶S(cathepsin S,Cat S)是半胱氨酸蛋白酶家族的重要成员,是一种溶酶体蛋白酶,在许多炎症过程和自身免疫疾病中表达。组织蛋白酶S在自身抗原递呈、损伤修复、体内炎症免疫、细胞增殖和凋亡等病理生理过程中发挥重要作用,与多种临床疾病的发生、进展和转归密切相关。该文就其结构组成、生物学特性、功能以及其在肾脏风湿系统疾病中的研究进展进行综述。

Cathepsin S(Cat S)is an important member of the cysteine cathepsin protease family.It is a lysosomal protease,which has been shown to be expressed in inflammatory conditions and autoimmune diseases.It has more specific roles such as antigen presentation,tissue repair,cell proliferation and apoptosis.It contributes to a variety of clinical diseases.In this review,we summarize the structure,characteristics and functions of cathepsin S in kidney and rheumatic diseases.