细胞因子与原发性肾病综合征发病机制研究进展

Research and progress of cytokines in pathogenesis of primary nephrotic syndrome

原发性肾病综合征(primary nephrotic syndrome,PNS)发病机制至今尚未阐明,目前认为主要与细胞免疫功能紊乱密切相关。近年来研究表明细胞因子参与了PNS的发生、发展。该文对目前报道的与PNS发病相关的细胞因子来源及其参与PNS发病的途径进行综述,阐明细胞因子参与PNS发病的可能机制,为细化PNS的分型及开发新的治疗靶点提供理论依据。

Primary nephrotic syndrome(PNS)is a common renal disease in children and the pathogenesis has not been clarified,but it is considered to be related to cellular immune dysfunction.We collected the reported cytokines associated with PNS and reviewed the resources and the involving pathogenesis of the cytokines.We hope to help to clarify the possible pathogenesis of PNS and to develop new treatments for PNS patients.