不同剂量阿托伐他汀钙联合双抗对急性脑梗死患者神经功能恢复的影响

Effect of different doses of atorvastatin calcium combined with double antibody on the recovery of neurological function in patients with acute cerebral infarction

目的探讨不同剂量阿托伐他汀钙联合双抗对急性脑梗死患者神经功能恢复的影响。方法选取2015年1月至2018年5月在南方医科大学珠江医院神经外科中心进行治疗的急性脑梗死患者共164例,采用随机数字法将患者分为研究组和对照组,每组82例,其中对照组采用小剂量阿托伐他汀钙联合双抗进行治疗,研究组采用大剂量阿托伐他汀钙联合双抗进行治疗。对比2组患者治疗前后的神经功能、血管内皮功能、血脂水平及神经体内指标。结果研究组的各项神经功能均优于对照组,差异具有统计学意义(P<0.05)。2组患者治疗前的各项功能指数比较,差异均无统计学意义(P>0.05);治疗后2组患者的血管内皮功能较治疗前有一定的改善,但组间比较差异无统计学意义(P>0.05);治疗后研究组患者的甘油三酯、血清总胆固醇、低密度脂蛋白胆固醇及高敏C反应蛋白水平的改善程度均优于对照组,差异有统计学意义(P<0.05),2组治疗后的高密度脂蛋白胆固醇水平比较,差异无统计学意义(P>0.05)。治疗后研究组患者的白细胞介素6水平明显低于对照组,差异有统计学意义(P<0.05),治疗后2组患者的血蓝蛋白与白细胞介素8水平比较,差异均无统计学意义(P>0.05)。结论大剂量的阿托伐他汀钙联合双抗对于急性脑梗死患者的神经功能恢复有着积极的作用,对其他体内水平有良好的影响,有利于改善预后。

Objective To explore the effect of different doses of atorvastatin calcium combined with double antibody on the recovery of neurological function in patients with acute cerebral infarction.Methods A total of 164 patients with acute cerebral infarction who were treated in Neurosurgical Center,Zhujiang Hospital,Southern Medical University from January 2015 to May 2018 were randomly divided into study group and control group,with 82 cases in each group.Among them,the control group was treated with low-dose atorvastatin calcium combined with double antibodies,the study group was treated with high-dose atorvastatin calcium combined with double antibodies.Compare the neurological function,vascular endothelial function,blood lipid level and neurosomatic index of the two groups before and after treatment.Results The neurological function of the study group was better than that of the control group,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there was no significant difference between the two groups(P>0.05);after treatment,the vascular endothelial function of the two groups was improved,but there was no significant difference between the two groups(P>0.05);after treatment,the improvement of triglyceride,serum total cholesterol,low density lipoprotein chesterol and high sensitive C-reactive protein levels of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in high density liptein cholesterol between the two groups(P>0.05).After treatment,the level of interleukin 6 in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,there was no significant difference between hemocyanin and interleukin 8 in the two groups(P>0.05).Conclusion Large dose of atorvastatin calcium combined with double anti-tumor has a positive effect on the recovery of neurological function in patients with acute cerebral infarction,has a good effect on other body levels,and is conducive to improving the prognosis.