长非编码RNA PCAT7对肌层浸润性膀胱癌发病的影响

Effect of Long Non-Coding RNA PCAT7 on Muscle Invasive Bladder Cancer

目的探讨长链非编码RNA PCAT7与膀胱癌的发病的相关性。方法收集2018年1—6月间确诊为肌层浸润性膀胱癌患者的膀胱黏膜组织标本61例、非肌层浸润性膀胱癌患者的膀胱黏膜组织标本52例和前列腺增生患者的正常膀胱黏膜组织标本23例,用RT-PCR检测标本中PCAT7和survivin的表达水平,并分析PCAT7的表达水平与膀胱癌的发病的相关性。结果在61例肌层浸润性膀胱患者的膀胱黏膜组织标本中PCAT7和survivin表达显著高于非肌层浸润性膀胱癌患者的膀胱黏膜组标本和正常膀胱黏膜组织标本(P<0.01),且二者的表达水平呈正相关(r=0.617,P<0.01)。结论PCAT7在肌层浸润性膀胱癌中显著高表达,并可能与膀胱癌的发病相关。

Objective To research the correlation between long non-coding RNA PCAT7 and bladder cancer.Methods Bladder mucosal specimens were collected from 61 cases of muscle invasive bladder cancer,52 cases of non-muscle invasive bladder cancer and 23 cases of prostatic hyperplasia who were diagnosed in our hospital from January June 2018.The expression of PCAT7 and survivin were determined by RT-PCR.Furthermore,the correlation between PCAT7 expression and bladder cancer was analyzed.Results The expression of PCAT7 and survivin in bladder mucosa in patients with muscle invasive bladder cancer were significantly higher than that in patients with non-muscle invasive bladder cancer or prostatic hyperplasia(P<0.01).There was a positive correlation between PCAT7 and surviving expression(r=0.617,P<0.01).Conclusion PCAT7 is highly expressed in muscle invasive bladder cancer and may contribute to the pathogenesis of bladder cancer.