四磨汤口服液对幼年巴马小型猪功能性消化不良腹泻的影响

Effect of Simo Decoction on Functional Dyspepsia with Diarrhea in Juvenile Bama Miniature pigs

目的:探讨四磨汤口服液对幼年巴马小型猪功能性消化不良腹泻的影响。方法:采用利血平注射液造成幼年巴马小型猪功能性消化不良腹泻模型。阳性对照组,四磨汤口服液低、中、高剂量组分别灌胃给予小儿复方鸡内金散药剂(0.14 g/kg)及低、中、高剂量四磨汤口服液(0.21、0.42、0.84 g生药/kg)。观察小型猪体质量、肛温、腹泻症状,ELISA法检测血清胃肠激素及尿D-木糖排泄率等功能性消化不良相关指标。结果:给药5 d后,四磨汤口服液中、高剂量组腹泻症状全部恢复,肛温均恢复正常;阳性对照组,四磨汤口服液中、高剂量组体质量增量明显高于模型对照组(P<0.01或P<0.05);四磨汤口服液中、高剂量组胆囊收缩素含量明显低于模型对照组(P<0.05),四磨汤口服液高剂量组淀粉酶、胃动素含量显著高于模型对照组(P<0.01或P<0.05)。结论:四磨汤口服液能剂量依赖性地改善功能性消化不良腹泻幼年巴马小型猪的腹泻症状,促进体质量增长,提高尿D-木糖排泄率,升高血清胃泌素、胃动素及淀粉酶含量,降低血清胆囊收缩素和乳酸含量。

Objective:To explore the effect of Simo decoction on functional dyspepsia with diarrhea in juvenile Bama miniature pigs.Methods:The model of functional dyspeptic with diarrhea in juvenile Bama miniature pigs was established by reserpine injection.The positive control group,Simo decoction low medium and high dose groups were respectively given pediatric compound chicken inner gold powder(0.14 g/kg)and different doses of Simo decoction(0.21,0.42 and 0.84 g/kg)by gavage administration.Body weight,anal temperature and symptom of diarrhea were observed.The serum gastrointestinal hormone and urinary D-xylose excretion rate were detected by ELISA.Results:After dosing five days,the symptoms of diarrhea and anus temperature were all recovered in Simo decoction medium and high dose groups;The positive control group,Simo decoction medium and high dose groups showed higher weight gain than the model control group(P<0.01 or P<0.05);The Simo decoction medium and high dose groups showed lower content of cholecystokinin than the model group(P<0.05);The Simo decoction high dose group showed higher amylase and motilin content than model group(P<0.01 or P<0.05).Conclusion:Simo decoction can improve the symptom of diarrhea,promote weight gain,increase D-xylose excretion rate and serum gastrin,motilin and amylase content,and reduced serum cholecystokinin and lactate content in juvenile Bama miniature pigs,in a dose-dependently manner.