基于磁共振T1图像的正常人脑组织体积量化研究

Volume quantification of normal brain tissues based on the magnetic resonance T1 images

目的 通过手动分割和自动分割得出正常人脑的总体积、脑脊液体积、灰质白质体积,分析不同性别的差异和随年龄变化的模式,同时给出可以得到较优结果的软件和参数。方法 通过软件自动分割得到粗略的脑掩模后进行手动精细分割,然后用FSL-FAST分为灰质、白质和脑脊液,最后用SPSS 25. 0。软件进行统计学分析。结果 中国正常成人脑总体积约1263. 24 ml,男性脑总体积(1313. 84 ml)大于女性脑总体积(1173. 11 ml),差异有统计学意义。不同年龄的脑总体积、灰质、白质和脑内脑脊液体积差异有显著性。灰质白质比与年龄无相关性。男性脑总体积、灰质、白质体积均大于女性,三者随年龄增大而降低的模式相似。女性脑总体积、灰质、白质体积随年龄变化的模式相似,在约50岁时达到最大值,随后体积逐渐减小。结论 不同性别人脑体积及灰质、白质、脑脊液体积随年龄变化作为鉴别正常脑体积变化与疾病导致的脑体积变化的依据。

Objective By manual and automatic segmentation,the total volume,cerebrospinal fluid volume and white matter volume of normal human brain were obtained,and the differences between different genders and the patterns of changes with age were analyzed.At the same time,we give the software and parameters that can get better result.Methods The rough brain mask was obtained by software automatic segmentation and it would be refined manually.Then the brain masks would be divided into gray matter,white matter and cerebrospinal fluid by FSL-FAST,and finally statistical analysis was performed with SPSS 25.0 software.Results The total brain volume of normal Chinese adults was about 1263.24 ml,and the total brain volume of males(1313.84 ml)was lager than the total volume of female brain(1173.11 ml).The difference was statistically significant.There were significant differences in total volume,gray matter,white matter and cerebrospinal fluid volume among different age groups.And there was no correlation between the age and the ratio of gray matter white matter.The total brain volume,gray matter,and white matter volume of males were larger than those of females,and as the age increases,the decline trend of these three sets of data is similar.The changes of total brain volume,gray matter volume and white matter volume with age were also similar in females.They reached their maximum at about 50 years of age,and then the volume gradually decreased.Conclusion The study on the changes of brain volume and the volume of gray matter,white matter and cerebrospinal fluid with age in different sexes can be used as a basis for identifying the changes of brain volume caused by diseases or the age.