更年期潮热的单胺类神经递质学说

Monoamine neurotransmitter theories of menopausal hot flashes

潮热是更年期女性最常见的症状,并且其症状与心血管疾病的发生密切相关,严重影响着更年期女性的身心健康,因此,避免和减轻更年期潮热的发生已经成为当今倍受关注的课题。目前,普遍认为潮热是由下丘脑体温调节中枢功能紊乱所致,但其确切的发病机制尚未阐明。最近的研究相继表明,更年期潮热是雌激素与多种神经递质交互作用的结果,其中单胺类神经递质去甲肾上腺素、5-羟色胺和多巴胺等起到了核心作用,现将其综述如下。

Hot flashes are the most common symptoms of menopausal women,and their symptoms are closely related to the occurrence of cardiovascular disease,which seriously affects the physical and mental health of menopausal women.Therefore,avoiding and alleviating the occurrence of hot flashes during menopause has become a topic of great concern today.It is generally believed that the hot flashes are caused by the dysfunction of hypothalamic thermoregulatory center,but its exact pathogenesis has not been elucidated.Recent studies have shown that menopausal hot flashes are the result of the interaction of estrogen with a variety of neurotransmitters,and monoamine neurotransmitters like norepinephrine,5-hydroxytryptamine and dopamine play a central role,which are summarized as follows.