异种生物材料应用于角膜移植的研究进展

Research Advances in Application of Xenogeneic Biomaterials in Corneal Transplantation

异种角膜材料和生物工程角膜材料的应用可以在一定程度上缓解人类供体角膜的紧张情况。供体脱细胞处理方式和手术方式上的改进使异种来源的角膜植片能够应用于临床治疗。猪眼角膜被认为是一种具备替代人供体的材料之一。目前,很多研究将猪来源的供体角膜作为异种移植材料,也在一定程度上取得了初步成果,这为临床试验的开展打下了基础。近年来很多关于脱细胞处理后的猪眼角膜应用于异种移植的研究相继被报道,未来猪眼角膜可能应用于临床以缓解临床供体的紧张现状。

The application of xenogeneic corneas or bioengineered corneal materials could relieve the tension of the human donor to a certain degree.With the improvement of decellularized technology and transplantation,the xenogeneic corneal materials can be used in the clinical treatment.Porcine cornea is considered to be one of the alternative materials for human donors.At present,many researches have explored the usage of porcine cornea as the xenogeneic graft,and have achieved preliminary results,which lays a foundation for the development of clinical trials.In recent years,many studies on the application of decellularized porcine corneas in xenotransplantation have been reported.Porcine cornea may be used in clinic to alleviate the tension of clinical donors in the future.