外泌体——卵巢癌诊治潜在新靶点

Exosomes-Potential New Targets for Diagnosis and Treatment of Ovarian Cancer

卵巢癌是妇科最常见的恶性肿瘤之一,具体发病机制尚不明确。外泌体是细胞释放的超微囊泡状物质,含有核酸、蛋白等生物活性分子,可在肿瘤细胞及肿瘤微环境物质之间进行信息传递,通过介导新生血管形成、重塑肿瘤微环境、调节免疫等过程参与肿瘤进展转移以及耐药等病理过程,为卵巢癌发病机制的研究开辟了新思路。此外,肿瘤细胞释放的外泌体还可存在于外周血,可能成为新型的肿瘤诊断生物标志物,对肿瘤发生进展中外泌体分子机制的研究,为卵巢癌治疗提供了新的思路。

Ovarian cancer is one of the most common malignant tumors in female reproductive system,the pathogenesis of which has not yet been clarified.Exosomes are tiny vesicles released from cells,containing nucleic acids and proteins,which can transmit information between tumor cells and tumor microenvironment substances,participating in the progression and drug resistance of tumors by mediating neovascularization,remodeling tumor microenvironment and regulating immunity,which provides a new way to study the pathogenesis of ovarian cancer.Moreover,exosomes produced by tumor cells can exist in serum,which can be considered as a biomarker of tumor diagnosis.It offers new ideas for the treatment of ovarian cancer by studying molecular mechanism of exosomes in tumor occurrence and progression.