益气活血方改善冠心病介入术后患者心脏功能与超敏C反应蛋白相关性的研究

The Correlation between Cardiac Function and Hypersensitivity C Reactive Protein in Patients of PCI with Coronary Heart Disease after YiQiHuoXuefang Intervention

目的:探讨益气活血方对冠心病介入术后心脏功能与超敏C反应蛋白的相关性。方法:150例冠心病行PCI术患者按随机数字表法分为两组,对照组75例予西医常规药物治疗,治疗组75例在对照组治疗基础上予加服益气活血方,分别于入院时、出院后60d、出院后180d观察两组MIDAS评分、超声心动图结果、血清C反应蛋白的差异。两组治疗疗程为3个月,随访时间为6个月。结果:治疗后两组患者的生命质量和心功能均较入院时改善,但在出院后两组患者的心功能、血清C反应蛋白具有明显差异性,出院后180d时实验组的生命质量和心功能改善程度较对照组更为显著(P<0.05)。实验组患者MIDAS评分在出院后180 d时明显高于对照组(P<0.05);实验组患者血清超敏C反应蛋白在出院180 d后明显低于对照组;在6个月的随访中,超声心动图结果表明实验组左室射血分数、每搏出量、左室舒张、收缩末期内径改善较对照组明显(P<0.05);在MACE发生率中,两组差异无统计学意义(P>0.05)。结论:益气活血方能够改善PCI术后康复期患者的心功能,且益气活血方可以显著降低冠心病介入术后患者炎性因子血清超敏C反应蛋白水平。

Objective:To investigate the correlation between cardiac function and hypersensitivity C reactive protein in patients of percutaneous coronary intervention(PCI)with coronary heart disease after the YiQiHuoXuefang intervention.Methods:150 patients with coronary heart disease after PCI are divided into two groups according to random number table method,the control group 75 participants were given to western medicine for conventional drug treatment,the other 75 participants of the treatment group were given the YiQiHuoXuefang,respectively on admission,discharge after 60 d,180 d after discharge observing two groups of MIDAS score,echocardiography results,the differences between the serum levels of c-reactive protein.Two groups of treatment course was 3 months and follow-up time was 6 months.Results:The quality of life and heart function of both groups after treatment were improved compared to the situation when admitted to hospital.However,there were significant differences in heart function and serum C reactive protein in the two groups after discharge,and the quality of life and heart function improvement in the experimental group was more significant than that of the control group at 180d after discharge(P<0.05).The MIDAS score of the patients in the experimental group were significantly higher than that of the control group at 180d after discharge from the hospital(P<0.05).Serum hypersensitivity C-reactive protein in the experimental group was significantly lower than the control group.In the follow-up time of 6 months,the results of the echocardiogram show that the experimental group had a significant improvement in the left-chamber blood score,the amount of per fight,the left chamber diastolic,and the end-stage shrinkage group(P<0.05).In MACE incidence,the difference between the two groups was not statistically significant(P>0.05).Conclusion:The YiQiHuoXuefang can improve the heart function of patients during PCI postoperative rehabilitation and also significantly reduce the level of inflammatory factor serum hypersensitivity C reactive protein.