基质金属蛋白酶在龋病中的研究进展

Research Progress of Matrix Metalloproteinases in Caries

基质金属蛋白酶(matrix metalloproteinases,MMPs)因其需要Zn^2+及Ca^2+作为辅助因子而得名,其家族成员能够降解大部分细胞外基质,牙本质中的Ⅰ型胶原蛋白也是其底物。多数研究表明,MMPs除参与颌面部肿瘤及黏膜疾病外,还参与了牙体软硬组织、根尖周及牙周组织的病变过程。MMPs不仅与牙体硬组织病变相关,在其修复及治疗过程中也发挥重要作用。无论在健康牙本质或是龋坏牙本质中均能检测到MMPs。本文就MMPs在龋病中的研究进展做一综述。

The proteolylic enzymes need Zn^2+ and Ca^2+ as cofactors,hence the name of matrix metalloproteinases(MMPs).Their family members can degrade most of the extracellular matrix.Type I collagen in dentin is also the substrate of MMPs.Most studies have shown that matrix metalloproteinases not only participate in maxillofacial neoplasms and mucosal diseases,but also participate in the pathological process of the soft and hard tissues of teeth,and periapical and periodontal lesions.MMPs have an vital function on the pathological changes of dental hard tissues and the process of restoration and treatment.MMPs can be detected,no matter whether it is sound or decayed dentin.This review has discussed the effect of MMPs in caries.