摘要
目的探讨改良国际预后指标(NCCN-IPI)对治疗结束后18F-FDG PET/CT评价为阴性的弥漫大B细胞淋巴瘤(DLBCL)患者的预后分层价值。方法回顾性分析2013年4月至2017年8月在苏州大学附属第一医院经过6~8周期R-CHOP类方案化疗后,并经18F-FDG PET/CT评价为阴性的60例DLBCL患者的临床资料,其中男性28例、女性32例,中位年龄51岁(16~81岁)。采用NCCN-IPI进行危险度分层,采用Log-rank检验比较各组间无进展生存(PFS)期和总生存(OS)期的差异。结果所有患者2年PFS率为83.33%(50/60),2年OS率为96.67%(58/60)。根据NCCN-IPI评分,低危组占35.0%(21/60),低中危组占41.7%(25/60),中高危组占18.3%(11/60),高危组占5.0%(3/60)。低危组与其他组间PFS差异有统计学意义(P=0.0272、0.0143、<0.0001),高危组与其他组间OS差异有统计学意义(P=0.0098、0.0166、0.0045),余各组间PFS及OS差异无统计学意义(均P>0.05)。结论应用NCCN-IPI可以对治疗结束后18F-FDG PET/CT评价为阴性的DLBCL患者进行进一步的预后分层。
Objective To investigate the prognostic stratification value of an enhanced international prognostic index(NCCN-IPI)in patients with diffuse large B-cell lymphoma(DLBCL)who are negative at the end of treatment with positron emission tomography computed tomography(PET/CT).Methods A retrospective analysis was conducted on 60 patients with DLBCL from April 2013 to August 2017 in the first affiliated hospital of Soochow university.There were 28 males and 32 females,with a median age of 51 years(16-81 years).Baseline characteristics were collected from all the patients who underwent six-to eight-cycle R-CHOP regimen chemotherapy and were negative by 18F-FDG PET/CT.The risk stratification was performed by NCCN-IPI,Log-rank test was used for comparison of the differences in progression-free survival(PFS)and overall survival(OS)between groups.Results The patients featured a median follow-up of 34 months(14-69 months).The two-year PFS and OS rates reached 83.33%(50/60)and 96.67%(58/60),respectively.On the basis of NCCN-IPI risk categorization,35.0%(21/60),41.7%(25/60),18.3%(11/60)and 5.0%(3/60)patients belonged to the low-,low-intermediate-,high-intermediate-,and high-risk subgroups,respectively.A statistically significant difference was observed in the PFS between the low-risk group and the other groups(P=0.0272,0.0143,<0.0001)and in the OS between the high-risk group and the other groups(P=0.0098,0.0166,0.0045).The difference between the PFS and OS of other components showed no statistical significance(all P>0.05).Conclusion Further prognostic stratification can be performed by NCCN-IPI in patients with DLBCL who are negative at the end of treatment by PET/CT.
作者
赵曼
吴翼伟
Zhao Man;Wu Yiwei(Department of Nuclear Medicine,the First Affiliated Hospital of Soochow University,Suzhou 215000,China)
出处
《国际放射医学核医学杂志》
2019年第5期427-431,共5页
International Journal of Radiation Medicine and Nuclear Medicine
关键词
弥漫大B细胞淋巴瘤
正电子发射断层显像计算机体层摄影术
国际预后指数
Diffuse large B-cell lymphoma
Positron emission tomography computed tomography
national comprehensive cancer network-international prognostic index