米诺环素联合长效西林对梅毒症状的治疗效果及对血清C反应蛋白和白细胞水平的影响

Effects of minocycline combined with Penzaethinum G on syphilis symptoms and serum CRP and WBC

目的探究米诺环素联合长效西林对梅毒症状的治疗效果及对血清C反应蛋白(commercial rent planning,CRP)、白细胞(white blood cell,WBC)水平的影响。方法选取进行治疗的梅毒患者130例,按照随机数字表法将所有入选患者分为长效西林组和联合治疗组两组各65例。长效西林组患者使用肌内注射长效西林的方法进行治疗,联合治疗组患者的治疗则是在长效西林组患者的治疗基础上使用米诺环素进行联合治疗。检测两组患者甲苯胺红不加热血清试验(TRUST)转阴情况以及皮损消退情况,对比两组患者治疗效果,检测治疗前后血清CRP、WBC水平,对比不良反应发生率。结果联合治疗组患者在治疗第1、2、3个月时间点TRUST检查转阴率均高于长效西林组(P<0.05);联合治疗组皮损消退率高于长效西林组(P<0.05);联合治疗组患者治疗总有效率高于长效西林组(P<0.05);联合治疗组临床症状消退时间和治愈时间均短于长效西林组(P<0.05);治疗后联合治疗组患者血清CRP、WBC水平低于长效西林组(P<0.05);联合治疗组不良反应发生率低于长效西林组(P<0.05)。结论使用米诺环素联合长效西林对梅毒患者进行治疗,能够加快患者临床症状消退时间及痊愈时间,调控血清CRP、WBC水平,治疗效果显著。

Objective To investigate the effect of minocycline combined with Penzaethinum G(PG)on the symptoms of syphilis and C-reactive protein(CRP)and white blood cells(WBCs).Methods Syphilis patients(n=130)who were treated in our hospital were selected.According to the numerical randomization method,all the enrolled patients were divided into the PG group and the combined treatment group.Patients in the PG group were treated with intramuscular injection of PG,while patients in the combined treatment group were treated with additional minocycline.The patients of the two groups were tested for TRUST conversion and skin loss regression.And the treatment effect was compared between the two groups.Serum CRP and WBC levels before and after treatment were measured,and the incidence rate of adverse reactions was compared.Results The conversion rate of patients in the combined treatment group was significantly higher than that in the PG group(P<0.05).The regression rate of skin lesions in the combined treatment group was significantly higher than that in the PG group(P<0.05).The total effective rate of the combined treatment group was significantly higher than that of the PG group(P<0.05).The clinical symptom resolution time and cure time of the combined treatment group were significantly shorter than that of the PG group(P<0.05).The serum CRP and WBC levels of patients in the combined treatment group were significantly lower than those in the PG group(P<0.05).The incidence of adverse reactions in the combined treatment group was significantly lower than that in the PG group(P<0.05).Conclusion Treatment of syphilis patients with minocycline combined with PG can accelerate the time of clinical symptoms resolution and recovery,regulate the level of serum CRP and WBC.