银杏内酯注射液治疗急性脑梗死疗效及对神经功能的影响

Effect of Ginkgolide injection in the treatment of acute cerebral infarction and its effect on nerve function

[目的]探讨银杏内酯注射液治疗急性脑梗死(ACI)的临床疗效及对神经功能的影响。[方法]将96例ACI患者按照随机数字表法随机分为2组,每组48例,对照组给予卧床休息、吸氧、营养脑细胞、改善脑循环、抗血小板聚集等常规治疗,治疗组在常规治疗基础上给予银杏内酯注射液静脉滴注,10 mL/次,1次/d,两组均连续治疗14 d。比较两组治疗前后国立卫生研究院卒中量表(NIHSS)评分、Barthel指数评分、血液流变学指标及血清血管内皮生长因子(VEGF)、血管生成素-Ⅱ(Ang-Ⅱ)和胶质纤维酸性蛋白(GFAP)水平,并比较两组总有效率。[结果]治疗后治疗组NIHSS评分低于对照组(P<0.01),Barthel指数评分高于对照组(P<0.01);血清VEGF、Ang-Ⅱ水平高于对照组(P<0.01),GFAP水平低于对照组(P<0.01);全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)和红细胞比容(HCT)均低于对照组(P<0.01),治疗总有效率高于对照组(P<0.05)。[结论]银杏内酯注射液治疗ACI有利于改善血液流变学指标、有效调节血清VEGF、Ang-Ⅱ、GFAP含量,改善神经功能,效果显著。

[Objective]To investigate the clinical efficacy of ginkgolide injection in the treatment of acute cerebral infarction(ACI)and its effects on nerve function.[Methods]The 96 patients with ACI were divided into two groups,with 48 cases in each group.The control group were given routine treatment such as bed rest,oxygen inhalation,nutrition of brain cells,improvement of cerebral circulation and anti-platelet aggregation.The treatment group were given intravenous drip of ginkgolide injection on the basis of routine treatment,10 mL/time,once a day.Both groups were treated continuously for 14 days.The National institutes of health stroke scale(NIHSS)score,Barthel index score,blood rheology index and serum levels of vascular endothelial growth factor(VEGF),angiopoietin-II(Ang-II)and glial fibrillary acidic protein(GFAP)before and after treatment were compared between the two groups.The total effective rate was compared between the two groups.[Results]After treatment,the NIHSS score of the treatment group was lower than that of the control group(P<0.01),the Barthel index score was higher than that of the control group(P<0.01),the serum levels of VEGF and Ang-II were higher than those of the control group(P<0.01),and the levels of GFAP were lower than that of the control group(P<0.01);The whole blood high shear viscosity(HSV),whole blood low shear viscosity(LSV),plasma viscosity(PSV)and red cell specific volume(HCT)were lower than those of the control group(P<0.01).The total effective rate of treatment was higher than that of control group(P<0.05).[Conclusion]Ginkgolides injection in the treatment of ACI is helpful to improve the hemorheological indexes.It can effectively regulate the contents of VEGF、Ang-II、GFAP,and improve the neurological function,and it has remarkable effects.