截骨术结合白芍总苷对强直性脊柱炎患者矢状位平衡与ESR的影响分析

Effect of osteotomy combined with TGP on sagittal balance and ESR in patients with ankylosing spondylitis

[目的]探讨截骨术结合白芍总苷对强直性脊柱炎患者矢状位平衡与红细胞沉降率(ESR)的影响。[方法]纳入择2012年8月—2017年2月在十堰市太和医院诊治的强直性脊柱炎患者110例作为研究对象,采用随机数字表法将研究对象分为观察组与对照组各55例,两组都给予截骨手术治疗,由同一组高年资关节外科医生主持下进行手术操作,对照组在术后给予常规治疗,观察组在对照组治疗的基础上给予白芍总苷治疗,治疗观察3个月。[结果]术后3个月观察组与对照组的总有效率分别为100.0%和87.3%,观察组的总有效率明显高于对照组(P<0.05)。观察组术后3个月的ESR与Cobb角分别为(15.33±8.24)mm/h和(-8.22±2.49)°,对照组分别为(24.42±5.39)mm/h和(-3.49±1.22)°,观察组明显低于对照组(P<0.05),且都明显低于术前(P<0.05)。观察组术后3个月的脑脊液漏、溃疡疾病、肝肾功能异常、切口感染等并发症发生率(3.6%)明显少于对照组(16.4%,P<0.05)。术后3个月两组的强直性脊柱炎功能指数(BASFI)评分都显著低于治疗前(P<0.05),观察组治疗后的强直性脊柱炎功能指数(BASFI)评分也显著低于对照组(P<0.05)。[结论]截骨术结合白芍总苷在强直性脊柱炎患者的应用有利于重建矢状位平衡,降低ESR,减少术后并发症的发生,促进缓解患者的临床症状,从而提高总体疗效。

[Objective]To investigate the effects of osteotomy combined with TGP on sagittal balance and ESR in patients with ankylosing spondylitis.[Methods]From August 2012 to February 2017,110 patients with ankylosing spondylitis in our hospital for treatment were selected as the research subject,all the patients were randomly divided into observation group and control group with 55 patients in each group.Two groups were given osteotomy surgery by the same group of senior surgeon,the control group was given postoperative routine treatment,the observation group was given postoperative TGP treatment based on the treatment,all patients were treated for 3 months.[Results]The postoperative 3 months total effective rates in the observation group and the control group were 98.2%and 87.3%respectively,and the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The postoperative 3 months of ESR and Cobb in the observation group were(15.33±8.24)mm/h and(-8.22±2.49)°,the control group were(24.42±5.39)mm/h and(-3.49±1.22)°,the observation group were significantly lower than the control group(P<0.05),and both were significantly lower than that preoperative(P<0.05).The postoperative 3 months of complication rate of cerebrospinal fluid leakage,ulcer disease,liver and kidney dysfunction,incision infection in the observation group was 3.6%that was significantly less than that of the control group(16.4%)(P<0.05).[Conclusion]Osteotomy combined with TGP in patients with ankylosing spondylitis is beneficial to reconstruct sagittal balance,reduce ESR,reduce postoperative complications and improve overall efficacy.