健脑补肾丸联合认知康复训练治疗脑卒中后认知功能障碍疗效及对血液流变学指标影响

Effect of Jiannaobushen pill combined with cognitive rehabilitation training on cognitive dysfunction after stroke and its effect on hemorheology

目的探讨健脑补肾丸联合认知康复训练治疗脑卒中后认知功能障碍患者的疗效及对血液流变学指标影响。方法选取成都市第二人民医院自2016年2月至2018年8月收治的100例卒中后认知功能障碍患者为研究对象。采用随机数字表法将其分为A、B两组,每组各50例。A组患者给予认知康复训练,B组患者在A组基础上给予健脑补肾丸。观察并比较两组患者的临床疗效及简易智能状态检查(MMSE)评分、蒙特利尔认知评定量表(MoCA)评分、Barthel指数评分量表(BI)评分。记录并比较两组患者的炎性因子及血液流变学指标水平。结果 B组患者的治疗总有效率为96.0%(48/50),显著高于A组的84.0%(42/50),差异有统计学意义(P>0.05)。治疗后,两组患者MMSE评分、MoCA评分与BI评分均显著升高,且B组高于A组,差异均有统计学意义(P<0.05)。治疗后,两组患者C反应蛋白(CRP)、白细胞介素-6(IL-6)水平及血浆黏度(PV)、血小板聚集率(PAR)、纤维蛋白原(FIB)和血细胞比容(HCT)水平均显著降低,且B组低于A组,差异均有统计学意义(P<0.05)。结论采用健脑补肾丸联合认知康复训练治疗脑卒中后认知功能障碍具有较好的临床疗效,安全性较高。

Objective To investigate the effect of Jiannaobushen pill combined with cognitive rehabilitation training on patients with cognitive dysfunction after stroke and its effect on hemorheology.Methods A retrospective study was performed on 100 cases of patients with cognitive dysfunction after stroke who were admitted from February 2016 to August 2018.Patients were randomly divided into the Group A and Group B,with 50 cases in each group.Patients in Group A were given cognitive rehabilitation training,and patients in Group B were given Jiannaobushen on the basis of Group A.The clinical efficacy and MMSE score,MoCA score and Barthel index score(BI)score between the two groups were observed and compared.The levels of inflammatory factors and hemorheological indicators in the two groups were recorded and compared.Results The total effective rate of treatment in Group B was 96.0%(48/50),which was significantly higher than that in Group A(84.0%,42/50),with statistically significant difference(P>0.05).After treatment,MMSE score,MoCA score and BI score were significantly increased in both groups,and Group B was higher than Group A,with statistically significant differences(P<0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),plasma viscosity(PV),platelet aggregation rate(PAR),fibrinogen(FIB)and hemocyte specific volume(HCT)in the two groups were significantly reduced,and the difference in Group B was lower than that in Group A(P<0.05).Conclusion Jiannaobushen pill combined with cognitive rehabilitation training in the treatment of cognitive dysfunction after stroke has a good clinical effect.It has high safety.