MMP-9和MTDH在乳腺癌中的表达及其临床病理学特征的关系

Expression and clinicopathological features of MMP-9 and MTDH in breast cancer

目的检测基质金属蛋白酶9(matrix metalloproteinase-9,MMP-9)及异黏蛋白(metadherin,MTDH)在乳腺非特殊型浸润性癌中的表达水平,探讨其与乳腺癌的临床病理关系。方法采用免疫组织化学法检测139例乳腺癌、64例癌旁组织中MMP-9、MTDH的表达情况,分析与乳腺癌患者的年龄、肿瘤大小、淋巴结转移、TNM分期、组织学分级的关系。结果MMP-9在乳腺癌中的阳性表达率为84.9%,高于癌旁组织(28.2%);MTDH的阳性表达率为76.9%,高于癌旁组织(34.4%),以上差异有统计学差异(P<0.05)。MMP-9和MTDH的表达与肿瘤大小、淋巴结转移、TNM分期、组织学分级相关,差异有统计学意义(P<0.05),而与患者的年龄无关(P>0.05)。MMP-9的表达与MTDH的表达间呈正相关(r=0.441,P<0.05)。结论MMP-9与MTDH在乳腺癌中均为高表达,两者的表达与肿瘤大小、淋巴结转移、TNM分期、组织学分级相关,提示两者在乳腺癌的发生、浸润、转移中具有重要意义。

Objective To explore the expressions of matrix mrtalloproteinase-9(MMP-9)and Metadherin(MTDH)in breast cancer,and analyze their clinicpathological features in breast cancer.Methods The immunohistochemistry Elivision method was used to detect the expression of MMP-9 and MTDH in 139 cases of breast cancer tissues,64 cases of adjacent normal tissues.Age,tumor size,lymph node metastasis,TNM stage,histological grade were analyzed for their correlation with expression of MMP-9 and MTDH.Results The positive expression rate of MMP-9 was 84.9%in breast cancer tissues,higher than 28.2%of adjacent normal breast tissues.The positive expression rate of MTDH was 76.9%in breast cancer tissues,higher than 34.4%of adjacent normal breast tissues(P<0.05).The expression rate of MMP-9 and MTDH were related with tumor size,lymph node metastasis,TNM stage,histological grade,but unrelated with age.The MMP-9 expression was positively correlated with MTDH(r=0.441,P<0.05).Conclusion There is high expression of MMP-9 and MTDH in breast cancer.MMP-9 is positively related with MTDH.Both are related with tumor size,lymph node metastasis,TNM stage,histological grade.It is suggested that both have important significance in the development,infiltration and metastasis of breast cancer.