胃癌和癌旁组织内IL-9、CXCR1表达情况与患者病情和生存预后的相关性

Correlation of the expressions of IL-9 and CXCR1 in gastric cancer and paracancerous tissues with the patients’ condition and survival prognosis

目的探讨胃癌及癌旁组织内白细胞介素-9(interleukin-9,IL-9)、CXC家族趋化因子受体(CXC chemokine receptor 1,CXCR1)表达水平及其与患者病情和生存预后的相关性。方法选取79例在徐州医科大学附属医院进行诊治的胃癌患者,采取免疫组织化学SP法检测胃癌组织及癌旁组织标本IL-9、CXCR1表达,分析IL-9、CXCR1表达与患者病情及预后生存的相关性。结果共收集有效癌症组织标本79例、癌旁组织标本79例,胃癌组织内IL-9、CXCR1阳性表达明显高于癌旁组织,差异有统计学意义(P<0.05)。在胃癌组织中IL-9与CXCR1表达具有相关性(P<0.05)。在胃癌组织内IL-9阳性表达与浸润深度、TNM分期及淋巴结转移相关(P<0.05),而CXCR1阳性表达与TNM分期及淋巴结转移相关(P<0.05)。胃癌患者IL-9、CXCR1阳性表达者预后生存期明显低于阴性者,差异有统计学意义(P<0.05)。将预后相关因素进行Cox多因素分析显示,淋巴结转移、TNM分期、IL-9表达、CXCR1表达是胃癌患者预后的独立影响因素(P<0.05)。结论胃癌组织中IL-9、CXCR1阳性表达明显升高,IL-9、CXCR1表达与胃癌患者病情及预后相关,IL-9、CXCR1阳性表达是影响胃癌患者预后生存期的独立因素。

Objective To investigate the correlation of the expressions of IL-9 and CXCR1 in gastric cancer and paracancerous tissues with the patients’condition and survival prognosis.Methods Seventy-nine patients with gastric cancer who were treated in the Affiliated Hospital of Xuzhou Medical University were enrolled.Immunohistochemical SP was used to detect the expressions of IL-9 and CXCR1 in gastric cancer tissues and paracancerous tissues.The correlation of the expressions of IL-9 and CXCR1 with patients’condition,prognosis and survival was analyzed.Results A total of 79 cancer tissues and 79 paracancerous tissues were collected.The expressions of IL-9 and CXCR1 in gastric cancer tissues were significantly higher than those in paracancerous tissues(P<0.05).There was a correlation between IL-9 and CXCR1 expression in gastric cancer tissues(P<0.05).The positive expression of IL-9 in gastric cancer tissues was correlated with depth of invasion,TNM stage and lymph node metastasis(P<0.05),while positive expression of CXCR1 was associated with TNM stage and lymph node metastasis(P<0.05).The prognostic survival of patients with gastric cancer with positive expression of IL-9 and CXCR1 was significantly lower than the negative ones,and the difference was statistically significant(P<0.05).Cox multivariate analysis was performed on prognostic factors.The results showed that lymph node metastasis,TNM stage,expressions of IL-9 and CXCR1 were independent prognostic factors for gastric cancer patients(P<0.05).Conclusion The expressions of IL-9 and CXCR1 are significantly increased in gastric cancer tissues.The expressions of IL-9 and CXCR1 are correlated with the condition and prognosis of gastric cancer patients.The positive expressions of IL-9 and CXCR1 are independent factors of affecting the prognosis of gastric cancer patients.