摘要
幽门螺杆菌(Helicobacter pylori,H.pylori)是高感染率的慢性致病菌,导致相关疾病的分子机制非常复杂。近年的研究发现,H.pylori在破坏胃上皮屏障的结构和功能中起重要作用,是H.pylori相关炎症和肿瘤转化的重要标志。本文主要阐述H.pylori致病因子包括空泡细胞毒素(VacA)、细胞毒素相关蛋白(CagA)、脲素酶(urease)和细胞蛋白酶等破坏胃上皮细胞间连接的分子机制。
Helicobacter pylori(H.pylori)is a chronic pathogen with high infection rate.Recent studies have found that H.pylori plays an important role in destroying the structure and function of the gastric epithelial barrier,which is an important marker of H.pylori-related inflammation and tumor transformation.This article mainly elaborated the molecular mechanism that pathogenic factors of H.pylori,including vacuolar cytotoxin(VacA),cytotoxin-related protein(CagA),urease and proteasome,which destroy the intercellular junction among gastric epithelial cells.
作者
崔国良
冯小可
魏睦新
CUI Guoliang;FENG Xiaoke;WEI Muxin(Department of Traditional Chinese Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210000;Institute of Integration of Chinese and Western Medicine,Nanjing Medical University,China)
出处
《胃肠病学和肝病学杂志》
CAS
2019年第12期1410-1413,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
江苏省中医药局科技项目(YB2015166)
关键词
幽门螺杆菌
致病因子
细胞间连接
发病机制
Helicobacter pylori
Pathogenic factors
Intercellular junction
Pathogenesis
