摘要
外泌体是一种由细胞主动分泌的囊泡样小体,研究发现外泌体在细胞与细胞之间起到信息交流以及免疫调控作用。近些年来,肿瘤微环境逐渐成为研究热点。研究发现,外泌体在许多病理状态,尤其是恶性肿瘤中具有不可替代的作用。本文着重介绍外泌体的提取、鉴定以及在部分妇产科疾病中的研究进展,并探索外泌体检测在妇产科疾病中的应用前景。
Exosomes are vesicle-like corpuscle actively secreted by cells.It has been found that exosomes play an important role in information exchange and immune regulation between cells and cells.In recent years,the tumor microenvironment has gradually become a research focus.Studies have found that exosomes have an irreplaceable role in many pathological conditions,especially malignant tumors.This article focuses on the extraction and identification of exosomes and its research progress in some gynecological diseases,and explores the application prospects of exosomes in gynecological diseases.
作者
马静
周琛斐
张延梅
王薇
MA Jing;ZHOU Chen Fei;ZHANG Yan Mei;WANG Wei(Department of Obstetrics and Gynecology,People*s Hospital of Three Gorges University,Yichang,Hubei 443000,China;Department of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Department of Gynecology and Obstetrics,the First Affiliated Hospital,Guangzhou Medical University,Guangzhou 511436,China)
出处
《中国妇幼卫生杂志》
2019年第6期94-98,共5页
Chinese Journal of Women and Children Health
基金
国家自然科学基金项目(81672589,81372781)
国家重点研发项目(2016YFC1302901)
南方医科大学“临床研究启动计划”项目(LC2016YM016)
深圳市科技计划项目(JCYJ20160429161218745)
关键词
外泌体
病理状态
研究进展
exosomes
pathological state
research progress
