血必净注射液对细菌性肝脓肿合并脓毒症患者的临床疗效观察

The clinical effect of Xuebijing on the patients with bacterial liver abscess and sepsis

目的观察血必净注射液在治疗细菌性肝脓肿(BLA)合并脓毒症患者中的临床效果.方法采用单中心、回顾性研究方法,收集2015年12月至2018年12月哈尔滨医科大学附属第一医院重症医学科收治的BLA合并脓毒症患者的临床资料;将患者分为对照组和观察组,应用常规治疗方案为对照组,在常规治疗方案基础上联合应用血必净注射液治疗为观察组;观察血必净注射液对BLA合并脓毒症患者的临床症状及肝脏功能的影响.结果与对照组比较,观察组患者住ICU总天数、发热天数与升压药物使用天数均缩短;治疗后两组患者的血白细胞计数(WBC)、降钙素原(PCT)和C-反应蛋白(CRP)均明显降低,但观察组以上指标下降更为明显(P<0.05);经治疗后两组患者谷丙转氨酶(ALT)、谷草转氨酶(AST)及总胆红素(TBIL)均明显降低,观察组以上指标下降更为明显(P<0.05).结论在常规治疗的基础上联合应用血必净注射液能够改善BLA合并脓毒症患者的临床症状与脏器功能,缩短治疗时间.

Objective To observe the effect of Xuebijing injection in the treatment of bacterial liver abscess(BLA)combined with sepsis.Methods A single-center,retrospective study was conducted to collect the clinical data of the patients with BLA and sepsis admitted from the department of Critical Care Medicine in the First Affiliated Hospital of Harbin Medical University,from December 2015 to December 2018.The patients were divided into control group and observation group randomly,only those who received conventional treatment were the control group,and those who received combined Xuebijing injection on the basis of conventional treatment were the observation group.The clinical efficacy of Xuebijing injection was compared between two groups.Results Compared with the control group,the days of ICU stay,fever days and the days of using vasopressors were shortened in the observation group.The WBC count,PCT and C-reactive protein levels were significantly lower in the observation group,there was statistical significance(P<0.05);ALT,AST and TBIL levels were significantly lower after the treatment,and the decrease in the observation group was more significant(P<0.05).Conclusion Combined application of Xuebijing injection on the conventional treatment could alleviate the clinical symptoms of patients with BLA and sepsis,shorten the treatment time and improve the treatment efficacy of patients.