影响儿童急性白血病发病的相关因素分析

Analysis of Related Factors Affecting the Nosopoiesis of Childhood Acute Leukemia

目的:主要从室内环境暴露与行为和生活方式的角度分析影响儿童急性白血病发病的相关因素。方法:回顾性分析本院64例初发急性白血病患儿的临床资料,另同期选取本院50例体检健康儿童为对照组。记录2组儿童的基本资料、室内环境暴露、行为及生活方式等情况。采用单因素和多因素Logistic回归分析影响儿童急性白血病发病的相关因素,并计算OR(95%CI)值。结果:单因素分析结果显示,急性白血病组父亲日常饮酒率和12个月内杀虫剂使用率较对照组明显升高(P<0.05)。多因素Logistic回归分析结果显示,儿童夏季睡眠时保持通风(OR=0.35,95%CI:0.14-0.88)和3岁前与其他儿童接触(OR=0.34,95%CI:0.18-0.65)均是防止儿童急性白血病发病的保护因素(P<0.05),母亲伴有化学物质接触史(OR=3.68,95%CI:1.64-8.27)、儿童伴有化学物质接触史(OR=3.84,95%CI:1.64-9.01)、儿童出生后家庭有室内装修史(OR=1.38,95%CI:1.05-1.81)、在儿童0-3岁期间家庭使用杀虫剂(OR=2.17,95%CI:1.08-4.36)均是影响儿童急性白血病发病的独立危险因素(P<0.05)。结论:室内环境暴露和儿童、父母行为及生活方式与儿童急性白血病的发病可能存在密切关系。

Objective:To analyze the related factors affecting the nosopoiesis of childhood acute leukemia from the perspective of indoor environmental exposure,behavior and lifestyle.Methods:The clinical data of 64 children with acute leukemia were retrospectively analyzed,and 50 healthy children were selected as the control group during the same period.The basic data of children,indoor environment,behavior and lifestyle of parents in 2 groups were recorded.Univariate and multivariate logistic regression analysis were used to analyze the related factors affecting the incidence of childhood acute leukemia,and the OR(95%CI)value was calculated.Results:The unvariate analysis showed that the daily wine-drinking rate of father and pesticide use rate in acute leukemia group were significantly higher than those in control group(P<0.05).Multivariate Logistic regression analysis showed that indoor ventilation during summer sleep of children(OR=0.35,95%CI:0.14-0.88)and contact with other children before 3 years old(OR=0.34,95%CI:0.18-0.65)were protective factors for provention of childhood acute leukemia(P<0.05).Mothers had a history of exposure to chemical substances(OR=3.68,95%CI:1.64-8.27),and children had a history of exposure to chemical substances(OR=3.84,95%CI:1.64-9.01),family had internal decoration history after child birth(OR=1.38,95%CI:1.05-1.81)and family uses of pesticides(OR=2.17,95%CI:1.08-4.36),all these factors were independent risk factors for acute leukemia(P<0.05).Conclusion:Indoor environmental exposure,behavior and lifestyle of children and parents may be closely related with the nosopoiesis of childhood acute leukemia.