鼓膜-听骨链精细三维重建及谐响应有限元分析

3D reconstruction of sophisticated eardrum-ossicular chain model and the harmonic response analysis calculated by finite element method

目的建立精细化的鼓膜-听骨链三维模型,并通过有限元方法进行生物力学分析,验证模型的合理性,为后续实验提供理论基础及依据。方法通过Micro-CT获取精细断层数据(螺距0.24mm,断层图像共464张),利用多软件综合处理,数字化重建鼓膜-听骨链,使用有限元进行谐响应振动力学分析,与激光多普勒在颞骨标本上获取的相应数据进行对比分析。结果数字化重建的鼓膜-听骨链模型,于100Hz、800Hz、8000Hz处,鼓膜数据采集点振幅分别为0.022μm、0.031μm、0.0041μm,镫骨足板数据采集点振幅分别为0.011μm、0.015μm、0.000069μm,各频率对应振幅与激光多普勒所得结果区间相符,趋势一致。结论利用该方法建立的模型,可以有效的数字化还原鼓膜-听骨链,后续可通过该模型,进一步实验分析听骨链生理及病理模型。

Objective To verify the reliability of the sophisticated eardrum-ossicular chain model and provide theoretical basis and reference for the follow-up experiments by using finite element method to analyze the harmonic response.Methods A sophisticated eardrum-ossicular chain model by multisoftware synthesized was established,by using Micro-CT and finite element method to obtain the fault data(screw pitch:0.24 mm,total cross sectional image:464 slices).The fault data were compared with the data which obtained from the temporal bone specimen scanned by laser doppler.Results The amplitudes of the tympanic membrane data collection points were 0.022,0.031 and 0.0041 microns at frequency of 100 Hz,800 Hz,8000 Hz respectively,and the amplitudes of the stapes plate data collection points were 0.011,0.015 and 0.000069 microns respectively.The result of the models’harmonic response was consistent with the result of laser doppler.Conclusions We can rebuild effectively a sophisticated eardrum-ossicular chain by establishing the model,we can use this model to analyze physiological function and pathologic change of the ossicular chain.