长链非编码RNA与急性髓系白血病基因型多样性关系的研究进展

Research Progress on the Relationship Between Long Non Coding RNA and Genetic Diversity in Acute Myeloid Leukemia

急性髓系白血病(AML)基因型的多样性是由个体在疾病发展过程中相继发生的遗传改变(如染色体变异)所致,这些基因突变干扰不同的细胞通路和功能,从而导致AML发生。近年来研究报道长链非编码RNA(lncRNA)与基因突变、基因表达异常等分子改变相关并影响白血病细胞的功能,对疾病的治疗和预后产生深远影响。因此,发现更多具有临床价值的分子标记将对疾病的临床表型和治疗反应产生深远的影响。本文就与AML基因型多样性相关的lncRNA调控机制做简要综述,以便对其有进一步了解。

The diversity of acute myeloid leukemia(AML)genotypes is caused by genetic changes such as chromosomal variations during the development of the disease.Long non-coding RNA(lncRNA)play more and more important roles in malignancies.Molecular changes such as gene mutation and gene expression abnormalities affect the function of AML cells,and may have a profound impact on the treatment and prognosis of diseases.The expanding knowledge in this field guiding for stratified therapy decisions and the development of targeted drugs,and is becoming an important part of modern personalized clinical management of AML.Here,we briefly summarized the regulatory mechanism of lncRNA related to AML genetic diversity to provide further system comprehensive knowledge about it.