子宫内膜样癌临床病理特征及分子学特点研究进展

Clinicopathological and Molecular Characteristics of Endometroid Endometrial Carcinoma

子宫内膜癌是一种高度异质性疾病,根据组织病理学类型可分为8类,其中子宫内膜样癌(EEC)最多见,约占内膜癌总数的85%。既往经验多认为该类内膜癌预后相对较好,但即使为低级别EEC,5年生存率也仅为75%~85%。不良预后结局可能与患者疾病诊断时的临床分期、组织病理学分级以及特殊基因型别等因素相关。本文从EEC临床、病理特征、分子学特点及其在相关治疗中的应用价值等方面,对近年来研究进行综述,以期为制定个体化临床治疗方案、改善患者预后提供参考。

Endometrial carcinoma is a heterogeneous disease with eight different histotypes.Endometrioid endometrial carcinoma(EEC)is the most common type accounting for approximately 85%of cases.Although most data indicate EEC has favorable prognoses,the five-year survival for EEC even with low-grade and early stage EEC is only 75%~85%.The poor outcome might be associated with tumor stage,grade,clinicopathological stratification and genomic classification.However,detailed pathophysiology of endometrial cancer has remained unclear in clinical or basic studies.Here,we presented recent evidence of clinicopathological and genetic foundations of EEC and also evaluated its corresponding therapeutic interventions,to provide novel targets and managements for further anti-carcinogenesis treatment.