全氟及多氟类化合物与卵巢癌关系的研究进展

Research Progress of the Relationship Between Perfluoroalkyl and Polyfluoroalkyl Substances and Ovarian Cancer

全氟和多氟烷酸类化合物(PFASs)是一类新型持久性有机污染物,其在环境和生物体内广泛存在,具有多方面毒性。已有部分实验和流行病学调查结果表明,PFASs暴露与女性卵巢癌有关。近年国内外关于PFASs与卵巢癌之间关系的报道不断增加,其中PFASs暴露的毒理学、表观遗传学及相应致癌机制等成为现今探讨的重要话题。综述PFASs与卵巢癌关系的最新研究进展,并对目前PFASs研究存在的问题及今后的研究方向进行讨论和展望。

Perfluorinated and polyfluoroalkyl substances(PFASs) are a new type of persistent organic pollutants(POPs) that are widespread in the environment and organisms and have many aspects of toxicity. Some experimental and epidemiological findings have shown that PFASs exposure is associated with ovarian cancer in women. In recent years, domestic and foreign reports on the relationship between PFASs and ovarian cancer have been increasing, among which the toxicology, epigenetics and the corresponding carcinogenic mechanism of PFASs exposure have become an important topic of discussion.This paper reviews the latest research progress on the relationship between PFASs and ovarian cancer, and discusses the existing problems and future research directions of PFASs.