C/EBPε对炎症和感染调控的研究进展

Progress of human CCAAT/enhancer binding protein epsilon on inflammation and infection

炎症和感染是造成危重病患者高病死率的主要原因之一,传统治疗措施单一且局限.人CCAAT/增强子结合蛋白epsilon(C/EBPε)是调节中性粒细胞终末分化的关键转录因子,它通过对炎症反应细胞的调控在抗炎、抗感染过程中起重要作用.本文通过对C/EBPε在炎症和感染中的变化、相关调控机制以及相关针对性逆转加强措施进行综述,旨在为发掘新的针对炎症及感染的治疗方向和有效治疗措施提供参考.

Inflammation and infection are main causes of death in critically ill patients.But traditional treatment are non-comprehensive and limited.Human CCAAT/enhancer binding protein epsilon(C/EBPε)is a key transcription factor regulating the terminal differentiation of neutrophils.It plays an important role in anti-inflammatory and anti-infective process by regulating inflammatory response cells.This article reviews the changes of C/EBPεin inflammation and infection,related regulatory mechanisms and targeted reversal measures,in order to provide references for exploring new directions and effective measures for inflammation and infection treatment.