摘要
危重病患者常存在免疫紊乱,儿茶酚胺在其发生发展中起重要作用.免疫细胞可合成儿茶酚胺和表达肾上腺素能受体.儿茶酚胺对中性粒细胞、单核/巨噬细胞、树突细胞、自然杀伤细胞等固有免疫和淋巴细胞为主介导的获得性免疫有广泛的调节效应,通过与免疫细胞上的α受体、β受体及多巴胺受体亚型结合,儿茶酚胺发挥了不同的免疫调节效应.深入探讨儿茶酚胺对重症患者免疫功能的调节效应及机制,将为危重病患者免疫功能障碍防治提供新思路.
Immune disorders are common in critically ill patients.Catecholamines play a crucial role in theimmune regulation and modulation.Immune cells can synthesize catecholamines and express adrenergic receptors.Catecholamine has a wide-ranging regulatory effect on innate immunity such as neutrophils,monocyte macrophages,dendritic cells,natural killer cells,and lymphocyte-mediated acquired immunity.Catecholamines exert different immunomodulatory effects by binding toαreceptors,βreceptors,and dopamine receptor subtypes on immune cells.In-depth study of the effect and mechanism of catecholamine on immune function in critically ill patients will provide new ideas for the prevention and treatment of immune dysfunction in critical illness.
作者
李超
刘军
吴允孚
Li Chao;Liu Jun;Wu Yunfu(Department of Critical Care Medicine,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou 215001,Jiangsu,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2019年第10期1295-1298,共4页
Chinese Critical Care Medicine
基金
江苏省苏州市科技发展计划(民生科技)项目(SS201874)
江苏省苏州市临床重点病种诊疗技术专项(LCZX201607)。
关键词
儿茶酚胺类
固有免疫
获得性免疫
免疫调节
Catecholamine
Innate immune
Acquired immune
Immunomodulatory effect
