高唾液酸修饰促进肿瘤免疫逃逸研究进展

Hypersialylation promotes tumor immune escape

唾液酸修饰是一种末端糖修饰,其可以在细胞膜表面糖蛋白或糖脂的糖链末端添加唾液酸,通过细胞与细胞间相互作用影响细胞生物学功能.在恶性肿瘤发生发展过程中,肿瘤细胞上的唾液酸修饰水平常显著升高,通过与免疫细胞上的唾液酸结合性免疫球蛋白样凝集素相互作用,诱导免疫抑制性肿瘤微环境,促进肿瘤免疫逃逸.唾液酸/唾液酸结合性免疫球蛋白样凝集素这对分子可能作为一种新的免疫检查点分子为肿瘤的免疫治疗提供新的思路.

Sialylation is one type of glycosylation that adds sialic acid residues to the tip of glycans in glycoprotein or glycolipid on cell membrane and participates in many critical cellular processes via cell-cell contact.The level of sialylation is usually elevated during carcinogenesis.Increased sialic acid could interact with Siglecs on the surface of immune cells,and thus induce immunosuppressive tumor microenvironment and tumor immune escape.It is believed that sialic acid-Siglecs can be served as novel immune checkpoints and bring hope to the development of immunotherapy in the future.