肺炎支原体肺炎患儿肺功能检测的临床意义

Clinical significance of pulmonary function detection in children with mycoplasma pneumonia

目的分析肺炎支原体肺炎(MPP)患儿急性期及恢复期肺功能的变化及其临床意义,为临床诊治提供参考。方法选取2015年6月-2017年6月在延安市人民医院住院的3~10岁肺炎支原体肺炎急性期(发病1周内)患儿60例为观察组,行常规肺功能检测,随访至恢复期(发病后第3周),再次行常规肺功能检测;另选取同期健康儿童60例作为对照组。结果观察组患儿急性期各项肺功能通气指标(FVC、FEV1、FEV1/FVC、PEF、MEF75、 MEF50、 MEF25、MMEF)较对照组均下降(t=-6.719、-6.835、-1.754、-6.171、-6.926、-5.661、-6.889、-6.874,P<0.05);恢复期各项指标均较急性期明显升高,与对照组比较,FVC、FEV1、FEV/FVC、PEF差异无统计学意义(P>0.05),而MEF75、 MEF50、 MEF25、MMEF仍明显降低(t=-2.306、-1.995、-3.305、-2.557,P<0.05)。结论 MPP患儿的肺功能在急性期均有不同程度损害,在恢复期大气道各项指标均基本恢复;小气道各项指标虽较急性期恢复,但未完全恢复正常。故在临床上需动态监测MPP患儿肺功能的变化,对治疗的评估和预后有一定的临床意义。

Objective To analyse the changes and clinical significance of pulmonary function in children with mycoplasma pneumoniae pneumonia(MPP) during acute and convalescent periods. Methods A total of 60 children aged 3 to 10 years with acute MPP in Yan′an People′s Hospital were selected as observation group from June 2015 to June 2017,and 60 healthy children were selected as control group at the same time.All children took routine pulmonary function test,and the observation group was followed up to the recovery period(on the third weeks after the onset). Results The indexes of pulmonary function ventilation(FVC,FEV1,FEV1/FVC,PEF,MEF75,MEF50,MEF25,MMEF) in the acute stage of MPP were significantly lower than those in normal control group(t=-6.719,-6.835,-1.754,-6.171,-6.926,-5.661,-6.889,-6.874,P<0.05).And all indexes in the recovery period obviously increased than the acute stage.Compared with the normal control group,FVC,FEV1,FEV1/FVC and PEF in the recovery period of MPP children recovered basically,while MEF75,MEF50,MEF25 and MMEF were still lower(t=-2.306,-1.995,-3.305,-2.557,P<0.05). Conclusions The pulmonary function of MPP children have different degrees of damage in the acute stage.All the indexes of large airway in the recovery period are basically recovered,but the indexes of small airway still not rise to the normal level.Therefore,it is necessary to dynamically monitor lung function in clinical practice,which is of great significance in the evaluation and prognosis of treatment of MPP children.