微创激素注入结合自固化磷酸钙人工骨修复骨囊肿患儿骨缺损的疗效

Efficacy of minimally invasive hormone injection combined with self-setting calcium phosphate cement in repairing bone defect of children with bone cyst

目的观察微创激素注入结合自固化磷酸钙人工骨(CPC)修复骨囊肿患儿骨缺损的临床疗效。方法骨囊肿手术患儿120例均分为两组。试验组注射醋酸强的松龙125 mg,骨缺损部注入填充位CPC;对照组实施传统开窗手术刮除病灶并灭活瘤腔,骨缺损部位填充自体骨或异体骨。术后评定两组疗效、骨愈合质量和骨缺损填充物降解率,记录术中和2年随访期内不良反应事件发生情况。结果试验组和对照组治愈率相仿(95.00%vs.86.67%)(P>0.05),试验组愈合时间短于对照组[(12.53±1.80)个月vs.(17.26±2.09)个月](P<0.05)。试验组复发3例,对照组复发8例。与对照组比较,试验组术后6个月、1年骨愈合质量评分较高,而骨缺损填充物降解率低(P<0.05)。两组均无不良反应事件发生。结论微创激素注入结合CPC修复骨囊肿患儿骨缺损疗效好,安全性高。

Objective To observe the clinical efficacy of minimally invasive hormone injection combined with self-setting calcium phosphate cement(CPC)in repairing bone defect of the children with bone cyst.Methods A total of 120 children with bone cyst was divided into two groups with 60 cases each.Prednisolone acetate 125 mg was injected and bone defect was filled with CPC in group A.Bone defect was transplanted with autografts or allogenic bone after the conventional fenestration was performed to scrape the lesion and inactivate the tumor cavity in group B.Clinical efficacy,bone healing quality and rate of bone filler degradation were evaluated.Adverse events were recorded during operation and within 2-year follow-up.Results The cure rate of groups of A and B was similar(95.00%vs.86.67%)(P>0.05).The healing time of group A was shorter than that of group B[(12.53±1.80)months vs.(17.26±2.09)months](P<0.05).There were 3 cases of recurrence in group A and 8 cases in group B.Compared with group B in the 6^th month and the 1^st year after operation,the bone healing quality score was higher,but rate of bone filler degradation was lower in group A(P<0.05).No adverse event was seen in two groups.Conclusion Minimally invasive hormone injection combined with CPC in repairing bone defect of the children with bone cyst is effective and safe.