雾化吸入布地奈德和地塞米松治疗小儿急性喉炎并呼吸困难的临床效果

Clinical effect of aerosol inhalation budesonide and dexamethasone in the treatment of pediatric acute laryngitis and dyspnea

目的分析雾化吸入布地奈德和地塞米松治疗小儿急性喉炎并呼吸困难的临床效果。方法选取我院2017年1月至2019年2月收治的86例急性喉炎并呼吸困难患儿作为研究对象,随机将其分为参照组(43例,雾化吸入地塞米松治疗)与观察组(43例,雾化吸入布地奈德治疗)。比较两组患儿的临床症状(呼吸困难、声音嘶哑、犬吠样咳嗽、吸气性喉鸣)消失时间、临床疗效、治疗前、后血清炎性因子水平及不良反应发生情况。结果治疗后,观察组的呼吸困难、声音嘶哑、犬吠样咳嗽及吸气性喉鸣临床症状消失时间均明显短于参照组,差异具有统计学意义(P<0.05)。观察组患儿的治疗总有效率为95.35%,明显高于参照组的69.77%,差异具有统计学意义(P<0.05)。治疗前,两组患儿的IL-6、TNF-α、CRP水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿的IL-6、TNF-α、CRP水平均降低,且观察组明显低于参照组(P<0.05)。观察组患儿用药后的不良反应总发生率为6.98%,明显低于参照组的27.91%,差异具有统计学意义(P<0.05)。结论雾化吸入布地奈德治疗小儿急性喉炎并呼吸困难的临床效果显著,可缩短患儿临床症状消失时间,改善其血清炎性因子水平,用药安全性较高,值得临床进一步应用。

Objective To analyze the clinical effect of aerosol inhalation budesonide and dexamethasone in the treatment of pediatric acute laryngitis and dyspnea. Methods A total of 86 children with acute laryngitis and dyspnea admitted in our hospital from January 2017 to February 2019 were selected as the study objects and randomly divided into reference group(43 cases, aerosol inhalation dexamethasonee treatment) and observation group(43 cases, aerosol inhalation budesonide treatment). The disappearance time of clinical symptoms(dyspnea, hoarseness, barking-like cough, inspiratory laryngitis),clinical effects, serum inflammatory factor levels before and after treatment and adverse reactions were compared between the two groups. Results After treatment, the disappearance time of clinical symptoms of dyspnea, hoarseness, barking-like cough and inspiratory laryngitis in the observation group were significantly shorter than those in the reference group, and the differences were statistically significant(P <0.05). The total effective rate of treatment in the observation group was95.35%, which was significantly higher than 69.77% in the reference group, and the difference was statistically significant(P<0.05). Before treatment, there were no significant differences in the levels of IL-6, TNF-α and CRP between the two groups(P >0.05);after treatment, the levels of IL-6, TNF-α and CRP in the two groups decreased, and those in the observation group were lower than the reference group(P<0.05). The total incidence of adverse reactions after medication was 6.98% in the observation group, which was significantly lower than 27.91% in the reference group, and the difference was statistically significant(P <0.05). Conclusion Aerosol inhalation budesonide in the treatment of pediatric acute laryngitis and dyspnea has a significant clinical effect, it can shorten the disappearance time of clinical symptoms, improve the level of serum inflammatory factors, and has a higher drug safety, which is worthy of further application in clinic.