为接受PCI的急性冠状动脉综合征患者用通心络联合替格瑞洛进行治疗的效果探究

To investigate the effect of tongxinluo combined with tigrillo in the treatment of patients with acute coronary syndrome who received PCI

目的:探究为接受经皮冠状动脉介入手术(PCI)的急性冠状动脉综合征患者使用通心络联合替格瑞洛进行治疗的效果.方法:将在吴忠市人民医院接受PCI的86例急性冠状动脉综合征患者作为研究对象.将这些患者随机分为对照组(n=42)和治疗组(n=44).对两组患者均进行PCI.在手术前后,为对照组患者使用替格瑞洛进行治疗,为治疗组患者使用替格瑞洛联合通心络进行治疗.然后,比较两组患者的TIMI血流分级、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、血小板聚集率、血清肌酸激酶同工酶(CK-MB)的水平、血清肌钙蛋白(cTnI)的水平、不良心血管事件(MACCE)的发生率及不良反应的发生率.结果:接受手术治疗后的第6个月,在治疗组患者中TIMI血流分级为Ⅲ级患者的占比高于在对照组患者中TIMI血流分级为Ⅲ级患者的占比,P<0.05.接受手术治疗后的第72 h,治疗组患者血清CK-MB及血清cTnI的水平均低于对照组患者,P<0.05.接受药物治疗后的第6个月,治疗组患者的LVEF高于对照组患者,其血小板的聚集率、MACCE的发生率及死亡率均低于对照组患者,其LVEDD小于对照组患者,P<0.05.接受药物治疗期间,两组患者出血的发生率及呼吸困难的发生率相比,P>0.05.结论:为接受PCI的急性冠状动脉综合征患者使用通心络联合替格瑞洛进行治疗的效果显著,且可降低其MACCE及不良反应的发生率.

objective:to investigate the efficacy of tongxinluo combined with tigrillo in the treatment of patients with acute coronary syndrome undergoing percutaneous coronary intervention(PCI).Methods:86 patients with acute coronary syndrome who received PCI in wuzhong people's hospital were studied.These patients were randomly divided into control group(n=42)and treatment group(n=44).PCI was performed in both groups.Before and after surgery,patients in the control group were treated with tigrillo and patients in the treatment group with tigrillo combined with tongxinluo.TIMI blood flow grade,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),platelet aggregation rate,serum creatine kinase isoenzyme(ck-mb)level,serum troponin(cTnI)level,incidence of adverse cardiovascular events(MACCE)and incidence of adverse reactions were then compared between the two groups.Results:6 months after surgery,TIMI flow in patients with treatment group class for ID patients in much higher than in the control group patients TIMI flow grade to grade HI the proportion of patients,P<0.05).At the 72nd h after surgical treatment,serum ck-mb and serum cTnl levels in the treatment group were lower than those in the control group(P<0.05).At the 6th month after drug treatment,patients in the treatment group had higher LVEF,lower platelet aggregation rate,MACCE incidence and mortality,and lower LVEDD than patients in the control group(P<0.05).The incidence of bleeding and dyspnea between the two groups was P>0.Conclusion:tongxinluo combined with tigrillo is effective in treating patients with acute coronary syndrome who receive PCI,and can reduce the incidence of MACCE and adverse reactions.