摘要
随着微生物组学在中枢神经系统疾病中研究的不断深入,肠道菌群在脊髓损伤中的作用也受到广泛关注。目前主要研究脊髓损伤后肠道菌群的变化特点及菌群代谢产生的芳香烃受体激动剂、短链脂肪酸和脂多糖等对损伤后继发性炎症反应的潜在影响,调节肠道菌群或补充菌群代谢产物可能是治疗脊髓损伤的一条潜在途径。
With the deepening of microbial research in central nervous system diseases, the role of gut microbiota in spinal cord injury has also received extensive attention. At present, it is mainly focused on exploring the changes of gut microbiota after spinal cord injury and the potential effects of aryl hydrocarbon receptor agonists, short-chain fatty acids and lipopolysaccharides produced by bacterial metabolism on secondary inflammation after injury, and it is recognized that gut microbiota or supplemental flora metabolites may be a potential pathway for the treatment of spinal cord injury.
作者
赵小华
周蕊寒
郭威
庞日朝
王文春
张安仁
ZHAO Xiao-hua;ZHOU Rui-han;GUO Wei;PANG Ri-zhao;WANG Wen-chun;ZHANG An-ren(School of Health and Rehabilitation,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075,China;Department of Rehabilitation Medicine,the General Hospital of Western Theater Command,Chengdu,Sichuan 610083,China;Pre-treatment Center of Leshan Traditional Chinese Medicine Hospital,Leshan,Sichuan 614000,China)
出处
《中国康复理论与实践》
CSCD
北大核心
2019年第12期1434-1438,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金项目(No.81674044)~~
关键词
脊髓损伤
肠道菌群
炎症
代谢产物
芳香烃受体
短链脂肪酸
脂多糖
综述
spinal cord injury
gut microbiota
inflammation
metabolites
aryl hydrocarbon receptor
short-chain fatty acids
lipopolysaccharides
review
