火针治疗寻常型银屑病有效性与安全性Meta分析

Meta Analysis on Efficacy and Safety of Fire Acupuncture in the Treatment of Psoriasis Vulgaris

目的:评价运用火针治疗寻常型银屑病的有效性、安全性。方法:运用计算机检索1996—2018年10月已发表在中国知网、万方、维普、中国生物医学文献数据库及pubmed中关于火针治疗银屑病的临床对照试验研究。采用Cochrane协作网提供的RevMan5.3软件进行分析。结果:共纳入17项随机对照试验,文献质量偏低,共1607例,对照组、试验组分别795、812例。Meta分析显示:对火针治疗寻常型银屑病的有效率进行分析,结果表明治疗组优于对照组,OR=3.06,95%CI(2.19,4.28),Z=6.56,P<0.001;11项研究对PASI评分进行分析结果表明:火针治疗寻常型银屑病对PASI评分改善优于其他非火针治疗,WMD=-2.65,95%CI(-3.92,-1.37),Z=4.06,P<0.001;3项研究对复发率进行比较,结果表明火针组的复发率低于其他对照组,OR=0.32,95%CI(0.17,0.60),Z=3.53,P<0.05;10项研究对不良反应进行比较,结果表明火针组的不良反应低于对照组0R=0.54,95%CI(0.32,0.93),Z=2.23,P<0.05。结论:火针治疗寻常型银屑病临床疗效值得肯定且安全性高。

Objective:To evaluate the efficacy and safety of fire acupuncture in the treatment of psoriasis vulgaris.Methods:Clinical controlled trials were retrieved in the databases of CNKI,Wanfang,VIP,Chinese biomedical literature and Pubmed from Jan.1996 to Oct.2018.RevMan5.3 software provided by Cochrane collaboration was used for the analysis.Results:A total of 17 randomized controlled trials(RCTs)were included.The quality of literature was relatively low,with a total of 1,607 participants(795 in the control group and 812 in the treatment group).Meta analysis showed that the effective rate was better in the treatment group than that in the control group(OR=3.06,95%CI(2.19,4.28),Z=6.56,P<0.001).The PASI score was analyzed in 11 studies,and the results showed that the improvement of PASI score in the fire acupuncture was better than that of the control group(WMD=-2.65,95%CI(-3.92,-1.37),Z=4.06,P<0.001).Three studies were conducted to compare the recurrence rate.The results showed that the recurrence rate of the fire acupuncture group was lower than that of the control groups(OR=0.32,95%CI(0.17,0.60),Z=3.53,P<0.05).Adverse reactions were compared in 10 studies,and the results showed that the adverse reactions in the fire acupuncture group were lower than those in the control group(OR=0.54,95%CI(0.32,0.93),Z=2.23,P<0.05).Conclusion:Fire acupuncture is effective for psoriasis vulgaris with high safety.