氧化三甲胺与慢性疾病关系的研究进展及测定方法概述

A review of the progress in relationship between trimethylamine oxide and chronic diseases and its determination

氧化三甲胺(TMAO)为肠道微生物代谢产物,是近年来被关注较多的缺血损伤标志物。随着对肠道菌群研究的不断深入,研究者发现TMAO与慢性疾病,尤其是心脑血管疾病、糖尿病、慢性肾脏病等的关系越来越密切。这些疾病通常潜伏期较长,临床症状不明显,病程常表现为不可逆,预后不良。因此,对这些慢性疾病早发现、早治疗尤为重要。本文简要总结了TMAO与上述慢性疾病的关系及现阶段测定TMAO的主要方法,以期为临床及早干预此类慢性疾病提供理论依据。

Trimethylamine oxide(TMAO),a metabolite of intestinal microorganisms,has been much focused on a marker of ischemic injury in recent years.With deepening research on the intestinal flora,researchers have found that TMAO is closely related to chronic diseases,especially cardiovascular and cerebrovascular diseases,diabetes,and chronic kidney disease.These diseases usually feature a long latent period,no obvious clinical symptoms,irreversible course,and poor prognosis.Therefore,early detection and treatment of these chronic diseases are particularly important.This article briefly summarizes the relationship between TMAO and the above chronic diseases and the main methods used to determine TMAO with a view of providing theoretical basis for early intervention of such chronic diseases.