摘要
房颤患者较非房颤患者卒中的风险高5倍,卒中中高风险的房颤患者长期有效的抗凝是至关重要的。本文阐述了维生素K拮抗剂与直接口服抗凝剂的药物特点及其优点与不足,并比较了房颤患者卒中预防中应用维生素K拮抗剂与直接口服抗凝剂的安全性及有效性,从而为患者选择维生素K拮抗剂治疗还是转为直接口服抗凝剂治疗提供一些实践指导。
The risk for stroke in the patients with atrial fibrillation(AF)was five folds as high as in those without.Long-term effective anticoagulation is crucial in the AF patients with moderate to high risk for stroke.This article highlights the characteristics,advantages and disadvantages of vitamin K antagonists(VKAs)against direct oral anticoagulants(DOACs),and discusses the safety and effectiveness of VKAs for the prevention of stroke in patients with AF as compared with DOACs.The article then provides practical guidance whether to stay on VKAs or switch from VKAs to DOACs.
作者
李娟
刘宏斌
温庆泽
李彦平
靳志涛
方芳
LI Juan;LIU Hong-Bin;WEN Qing-Ze;LI Yan-Ping;JIN Zhi-Tao;FANG Fang(Cadre′s Ward,Beidaihe Rehabilitation and Recuperation Center of PLA,Qinhuangdao 066100,China;Department of Cardiology,the Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Outpatient Clinic,32734 Troops of PLA,Tianjin 300182,China;Department of Cardiology,Rocket Force Characteristic Medical Center of PLA,Beijing 100088,China;Department of Cardiology,Chinese PLA Hospital No.951,Korla 841000,China)
出处
《中华老年多器官疾病杂志》
2019年第12期956-960,共5页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
抗凝剂
房颤
维生素K拮抗剂
X因子抑制剂
卒中
anticoagulants
atrial fibrillation
vitamin K antagonists
factor Xa inhibitors
stroke
