轻型缺血性脑卒中患者卒中后抑郁的相关因素研究

Study of relative factors of post-stroke depression on patients with mild ischemic stroke

目的探讨轻型缺血性脑卒中患者卒中后抑郁(post-stroke depression,PSD)的相关因素。方法连续选取2017-08-2018-10就诊于中国人民解放军联勤保障部队第989医院的首发轻型缺血性脑卒中患者共150例,采用HAMD评分将其分为PSD组55例和N-PSD组95例。结果轻型缺血性脑卒中患者PSD的发生率为36.7%,组间比较发现女性(P=0.014,OR=1.169,95%CI 1.210~3.664)和2型糖尿病(P=0.021,OR=4.813,95%CI 2.180~7.964)为PSD的独立危险因素。2组不同卒中部位的比较无统计学意义(P>0.05)。PSD组社会支持总分、主观支持和支持利用度明显低于N-PSD组(P<0.05)。结论轻型缺血性脑卒中患者PSD的发生率较高,女性、2型糖尿病、缺乏社会支持可能是其危险因素,并未发现卒中部位与PSD的发生有关。

Objective To explore the prevalence and predictors of post-stroke depression in patients with mild ischemic stroke.Methods 150 patients with first-ever mild ischemic stroke from August 2017 to October 2018 were selected for the study.All the patients were classified into PSD group(55 cases) and N-PSD group(95 cases) according to the score of HAMD.Results The prevalence of PSD in patients with after mild ischemic stroke was 36.7%.Female gender(P=0.014,OR=1.169,95% CI 1.210-3.664) and diabetes(P=0.021,OR=4.813,95% CI 2.180-7.964) were the risk factors significantly correlated with PSD.No correlation was observed between lesion site or side and the development of PSD.The total score of social support,the score of subjective support and support utilization in PSD group were lower than those in N-PSD group(P<0.05).Condusion The prevalence of PSD is high after mild ischemic stroke.Female gender,diabetes and lack of social support may be risk predictors for PSD.No correlation was observed between lesion site or side and the development of PSD.