摘要
目的:探讨妊娠期糖尿病患者脂肪细胞因子与TLR4/MyD88信号通路相关蛋白的关系研究。方法:选取2015年2月~2017年12月于中国人民解放军白求恩国际和平医院诊断治疗的妊娠期糖尿病患者,共计79例为研究对象,分析脂肪细胞因子与TLR4/MyD88信号通路相关蛋白的相关性。结果:经Pearson法分析,结果显示脂肪细胞因子和TLR4/MyD88信号通路相关蛋白表达具有相关性(P<0.05);TLR4、MyD88、TRAF-6、NF-κB、IL-1β均与FBG、PBG以及HOMA-IR相关联(P<0.05)。结论:妊娠期糖尿病患者可分泌大量脂肪细胞因子,且脂肪细胞因子与TLR4/MyD88信号通路相关蛋白均可能参与病情进展。
Objective:To investigate the relationship between adipocytokines and TLR4/MyD88 signaling pathway-related proteins in gestational diabetes mellitus.Methods:A total of 79 patients with gestational diabetes mellitus who diagnosed and treated in China People′s Liberation Army Bethune International Peace Hospital from February 2015 to December 2017 were selected as the subjects and defined as the observation group.The correlation between adipocytokines and TLR4/MyD88 signaling pathway related proteins was analyzed.Results:Analysis by Pearson method,the results showed that there was a correlation between adipocytokines and TLR4/MyD88 signaling pathway-related protein expression(P<0.05);TLR4,MyD88,TRAF-6,NF-κB and IL-1βwere all associated with FBG,PBG and HOMA-IR(P<0.05).Conclusion:The patients with gestational diabetes can secrete a large number of adipocytokines,and both the adipocytokines and TLR4/MyD88 signaling pathway related proteins may participate in the progression of the disease.
作者
郭志利
姚玉英
姚克青
张梅
于洪斌
苗莉娜
王茹
尹晓琳
GUO Zhi-Li;YAO Yu-Ying;YAO Ke-Qing;ZHANG Mei;YU Hong-Bin;MIAO Li-Na;WANG Ru;YIN Xiao-Lin(Department of Microbiology and Immunology of Shijiazhuang Medical College,Shijiazhuang 050599,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第23期2908-2910,共3页
Chinese Journal of Immunology
基金
2014年河北省省级科技计划项目(No.H2014206212)
关键词
妊娠期糖尿病
脂肪细胞因子
髓样分化因子88
相关性
Gestational diabetes mellitus
Adipocytokines
Myeloid differentiation factor 88
Correlation