杭白菊化学成分的研究

Chemical constituents from Chrysanthemum morifolium

目的研究杭白菊Chrysanthemum morifolium Ramat.的化学成分。方法杭白菊80%乙醇提取物的正丁醇部位采用大孔吸附树脂、Sephadex LH 20和制备液相进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到12个化合物,分别鉴定为茵芋苷(1)、吲哚3甲酰基βD吡喃葡萄糖苷(2)、3 deoxybidensyne oside B(3)、pollenopyrroside A(4)、2 epi acotatarin A(5)、1核糖醇基2,3二酮1,2,3,4四氢6,7二甲基喹喔啉(6)、2(furan-2′-yl)5(2″R,3″S,4″trihydroxybutyl)1,4 diazine(7)、腺苷(8)、3,4二羟基苯甲醛(9)、2,4二羟基苯甲醛(10)、香草酮(11)、4羟基苯丙醛(12)。结论所有化合物均为首次从该植物中分离得到。

AIM To study the chemical constituents from Chrysanthemum morifolium Ramat..METHODS The n butanol fraction of 80%ethanol extract of C.morifolium was isolated and purified by macroporous absorption resin,Sephadex LH 20 column and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twelve compounds were isolated and identified as skimmin(1),indole 3 carboxylβD glucopyranoside(2),3 deoxybidensyneoside B(3),pollenopyrroside A(4),2 epi acotatarin A(5),1 ribityl 2,3 diketo 1,2,3,4 tetrahydro 6,7 dimethyl quinoxaline(6),2(furan-2′-yl)-5-(2″R,3″S,4″trihydroxybutyl)1,4 diazine(7),adenosine(8),3,4 dihydroxy benzal dehyde(9),2,4 dihydroxy benzaldehyde(10),acetovanillone(11),4 hydroxyphenyl propanal(12).CONCLUSION All the compounds are isolated from this plant for the first time.