慢性心力衰竭患者静息心率与血清超敏C反应蛋白、脑钠肽及左室射血分数的相关性

Correlation between resting heart rate and serum high sensitive C reactive protein,brain natriuretic peptide and left ventricular ejection fraction in patients with chronic heart failure

目的探讨慢性心力衰竭(CHF)患者静息心率(RHR)与血清超敏C反应蛋白(hs-CRP)、脑钠肽(BNP)及左室射血分数(LVEF)的相关性.方法选取120例慢性心力衰竭患者,根据RHR分为A组37例(RHR<70次/min)、B组45例(RHR为70~90次/min)和C组38例(RHR>90次/min).入院时检测并比较3组血清hs-CRP、BNP、LVEF水平.采用Pearson法分析RHR与血清hs-CRP、BNP、LVEF水平的相关性.结果C组纽约心脏学会(NYHA)分级Ⅲ~Ⅳ级患者比例显著高于A组、B组(P<0.05).A组、B组、C组血清hs-CRP、BNP水平依次升高,LVEF依次下降,组间两两比较,差异均有统计学意义(P<0.05).Pearson法分析显示,CHF患者RHR与血清hs-CRP、BNP均呈显著正相关(r=0.493、0.572,P=0.034、0.027),与LVEF呈显著负相关(r=-0.518,P=0.031).结论CHF患者RHR与hs-CRP、BNP水平呈显著正相关,与LVEF呈显著负相关.

Objective To investigate the correlation between resting heart rate(RHR)and serum high-sensitivity C reactive protein(hs-CRP),brain natriuretic peptide(BNP)and left ventricular ejection fraction(LVEF)in patients with chronic heart failure(CHF).Methods A total of 120 patients with CHF were divided into group A with RHR less than 70 times per minute(n=37),group B with RHR from 70 to 90 times per minute(n=45)and group C with RHR over 90 times per minute(n=38).The levels of hs-CRP,BNP and LVEF were measured and compared among three groups.Pearson method was used to analyze the correlation between RHR and hs-CRP,BNP and LVEF.Results The proportion of patients with gradeⅢtoⅣof New York Heart Association(NYHA)in group C was significantly higher than that in group A and group B(P<0.05).The levels of hs-CRP and BNP in group A,B and C increased in proper order,while LVEF decreased in proper order,and there were significant differences among three groups(P<0.05).Pearson analysis showed that RHR was positively correlated with hs-CRP and BNP(r=0.493,0.572,P=0.034,0.027)and negatively correlated with LVEF(r=-0.518,P=0.031).Conclusion RHR is positively correlated with hs-CRP,BNP and negatively correlated with LVEF in CHF patients.