脑卒中后抑郁治疗前后血清皮质醇水平的表达及其与抑郁的相关性分析

Expression of serum cortisol levels in post-stroke depression patients before and after treatment and its correlation with depression

目的评价血清皮质醇水平在脑卒中后抑郁患者治疗前后的表达及其与抑郁的相关性.方法随机选取本院收治的56例脑卒中后抑郁患者作为观察组,选取同期收治的56例脑卒中未合并抑郁患者作为对照组.检测2组患者血清皮质醇水平,探讨其与脑卒中后抑郁的相关性.结果观察组治疗前后血清皮质醇表达水平均高于对照组,差异有统计学意义(P<0.05);观察组治疗后汉密尔顿抑郁量表(HAMD)评分低于治疗前,差异有统计学意义(P<0.05);Logistic线性回归分析表明,血清皮质醇与脑卒中后抑郁呈正相关.结论血清皮质醇水平的表达与脑卒中后抑郁患者的发病有密切相关性.

Objective To evaluate the expression of serum cortisol in patients with post-stroke depression before and after treatment,and its correlation with depression.Methods A total of 56 patients with post-stroke depression admitted in our hospital were randomly selected as observation group and another 56 patients without depression in the same period were selected as control group.The serum cortisol level of the two groups was detected,and the correlation between the serum cortisol level and post-stroke depression were explored.Results The levels of serum cortisol expression in the observation group before and after treatment were significantly higher than that in the control group,and Hamilton Depression Scale(HAMD)scores of the observation group after treatment was lower than that in the control group(P<0.05).Logistic linear regression analysis showed that the serum cortisol level was positively correlated with post-stroke depression.Conclusion The expression of serum cortisol level is closely correlated with the incidence of depression after stroke.