匹维溴铵联合伊托必利对功能性消化不良患者胃肠动力的影响分析

Effect of Pivonium Bromide Combined with Itopride on Gastrointestinal Dynamics in Patients with Functional Dyspepsia

目的:将匹维溴铵与伊托必利联合用于功能性消化不良患者治疗中,分析其对患者胃肠动力的影响。方法:对我院收治的93例功能性消化不良患者分组研究,参照组行伊托必利治疗,实验组在此基础上联合匹维溴铵治疗,对两组治疗结果进行评价。结果:两组治疗前各项胃肠激素水平相比,差异不显著(P>0.05),实验组治疗后胃动素(MTL)、一氧化氮(NO)水平与参照组相比,相对更高,5-羟色胺(5-HT)水平与参照组相比,相对更低(P<0.05);两组治疗前腹痛、腹泻评分相比,差异不显著(P>0.05),实验组治疗后腹痛、腹泻评分与参照组相比,均相对更低(P<0.05);实验组总有效率为95.74%,与参照组(73.91%)相比,相对更高(P<0.05);实验组用药期间不良反应率为4.26%,与参照组(21.74%)相比,相对更低(P<0.05)。结论:对功能性消化不良患者而言,应用匹维溴铵与伊托必利联合治疗效果显著,可促进患者胃肠动力,改善腹痛、腹泻等症状,且不良反应较少,安全有效,值得应用。

Objective:To analyze the effect of pivobromide combined with etopride on gastrointestinal motility in patients with functional dyspepsia.Methods:93 patients with functional dyspepsia in our hospital were divided into two groups.The control group was treated with etopril,and the experimental group was treated with pivobromide on this basis.The treatment results of the two groups were evaluated.Results:There was no significant difference in the levels of gastrointestinal hormones between the two groups before treatment(P>0.05).After treatment,the levels of MTL and NO in the experimental group were higher than those in the control group,and the levels of 5-HT were lower than those in the control group(P<0.05).There was no significant difference in the scores of abdominal pain and diarrhea before treatment between the two groups(P>0.05).After treatment,the scores of abdominal pain and diarrhea in the experimental group were higher than those in the control group The total effective rate of the experimental group was 95.74%,which was higher than that of the control group(73.91%),P<0.05;the adverse reaction rate of the experimental group was 4.26%,which was lower than that of the control group(21.74%),P<0.05.Conclusion:For patients with functional dyspepsia,the combination of Pivonium Bromide and Itopride is effective and safe.It can promote gastrointestinal motility,improve symptoms of abdominal pain and diarrhea,and has fewer adverse reactions.