人类抗菌肽CAMP及其活性产物LL-37在疾病发生发展中的作用

The role of human cathelicidin antimicrobial peptide and its active product LL-37 in the occurrence and development of diseases

人类抗菌肽CAMP及其活性产物LL-37(CAMP/LL-37)具有广谱的抗菌作用,也具有免疫调节、损伤修复的作用,在细胞增殖、侵袭、调节细胞周期及凋亡等方面也发挥了重要的生理功能。本文主要阐述了CAMP/LL-37在感染性疾病、自身免疫性疾病、肿瘤等疾病发生发展中的作用及机制,并对该领域的研究趋势进行了展望。

Human cathelicidin antibacterial peptide(CAMP)and its active product LL-37(CAMP/LL-37)have a broad-spectrum antibacterial effect,and also have immunoregulatory and damage repair effects.It also plays an important physiological role in cell proliferation,invasion,regulation of cell cycle and apoptosis.This article mainly describes the role and mechanism of CAMP/LL-37 in the occurrence and development of infectious diseases,autoimmune diseases,tumors,etc.,and forecasts the research trends in this field.