达标治疗在2型糖尿病领域的应用

Treat-to-Target Approach in T2DM

"Treat-to-target"(达标治疗)理念为慢性疾病的达标管理开辟了新思路。继2003年首个糖尿病领域广受认可的"Treat-to-target"研究问世后,该理念在糖尿病管理中的运用越发受到重视。已有证据表明,糖尿病综合管理中合理应用"Treat-to-target"理念,有助于评估降糖治疗方案的疗效、安全性及其他临床获益,有利于临床医生制定良好的治疗决策,继而帮助患者实现个体化的血糖达标。为了更好地将"Treat-to-target"理念应用于胰岛素治疗,需综合考虑目标值的设定、剂量调整方式与方案、终点剂量、调整/达标周期等多个方面。

Treat-to-target strategy opened up a new way to standard-achieving management of chronic diseases. Since the first treat-to-target study made its debut in 2003 of diabetes field, more and more attentions had been paid to treat-to-target strategy in diabetes management. Evidences had shown that the application of treat-to-target strategy on comprehensive diabetes management would contribute to not only evaluation on efficacy, safety and other clinical benefits of hypoglycemic therapy, but also improvement on medical decision making by clinicians. All above could favor individualized glucose targeting achievement. For facilitating the application of treat-to-target strategy on insulin therapy, there was a great need to refine comprehensively target setting, dosage titration style and strategy, end-point dosage, and titration/targeting cycle and other aspects.