奥曲肽联合泮托拉唑治疗老年消化性溃疡合并上消化道出血患者的疗效及对凝血功能的影响

Effect of octreotide combined with pantoprazole for elderly patients with peptic ulcer complicating upper gastrointestinal bleeding and its influence on coagulation function

目的探讨奥曲肽联合泮托拉唑治疗老年消化性溃疡合并上消化道出血患者的疗效及对凝血功能的影响。方法选取100例老年消化性溃疡合并上消化道出血患者为研究对象,分为对照组(单纯给予泮托拉唑治疗)与实验组(给予奥曲肽、泮托拉唑联合治疗),各50例,比较2组患者预后。结果实验组治疗72 h的有效止血率高于对照组,治疗总有效率高于对照组,差异有统计学意义(P<0.05);实验组患者治疗72 h后凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)均优于对照组,差异有统计学意义(P<0.05);2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥曲肽联合泮托拉唑对老年消化性溃疡合并上消化道出血患者的治疗效果显著优于单纯泮托拉唑治疗。

Objective To observe the effect of octreotide combined with pantoprazole in the treatment of elderly patients with peptic ulcer complicating upper gastrointestinal bleeding and its effect on blood coagulation function.Methods A total of 100 elderly patients with peptic ulcer and upper gastrointestinal bleeding admitted to our hospital were divided into control group and experimental group.The control group(n=50)was treated with pantoprazole alone,while the experimental group(n=50)was treated with octreotide and pantoprazole.The prognosis of the two groups was compared.Results The effective hemostasis rate after 72 h of treatment,the total effective rate in the experimental group was significantly higher than that in the control group(P<0.05).Prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)at 72 hours after treatment in the experimental group were better than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Octreotide combined with pantoprazole has better efficacy than pantoprazole alone in the treatment of elderly peptic ulcer patients with upper gastrointestinal bleeding.